← Mechanisms of action
MET
SINGLE PROTEINHomo sapiens
Preferred name: Hepatocyte growth factor receptor ChEMBL ↗
Linked proteins
Drugs acting on this target (98)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| ckd-703 | — | experimental | mAb | MET |
| ath-1017 | Activator | experimental | Small molecule | MET activator |
| ang-3777 | Agonist | experimental | Small molecule | MET agonist |
| ath-1020 | Agonist | experimental | Small molecule | MET agonist |
| gen1286 | Antagonist | experimental | mAb | MET antagonist |
| MCLA-129 | Antagonist | experimental | mAb | Met |
| onartuzumab | Antagonist | experimental | mAb | MET antagonist |
| jnj-75220795 | Antisense inhibitor | experimental | Nucleic acid | MET antisense inhibitor |
| abbv-303 | Binding agent | experimental | mAb | MET binding agent |
| byon3521 | Binding agent | experimental | mAb | MET binding agent |
| mytx-011 | Binding agent | experimental | mAb | Met |
| rc108 | Binding agent | experimental | mAb | MET binding agent |
| telisotuzumab vedodin (Emrelis) | Binding agent | approved | mAb | Hepatocyte growth factor receptor binding agent |
| c-met/pd-l1 car-t cell | Immunity, passive | experimental | Cell therapy | MET immunity, passive |
| cmet cart cells | Immunity, passive | experimental | Cell therapy | MET immunity, passive |
| abbv-400 | Inhibitor | experimental | mAb | MET inhibitor |
| abn401 | Inhibitor | experimental | Small molecule | MET inhibitor |
| ad 337 | Inhibitor | experimental | Small molecule | MET inhibitor |
| al2846 | Inhibitor | experimental | Small molecule | MET inhibitor |
| altiratinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| amg-208 | Inhibitor | experimental | Small molecule | MET inhibitor |
| amg-337 | Inhibitor | experimental | Small molecule | MET inhibitor |
| amivantamab-vmjw (Rybrevant) | Inhibitor | approved | mAb | Hepatocyte growth factor receptor inhibitor |
| amuvatinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| ans014004 | Inhibitor | experimental | Small molecule | MET inhibitor |
| apl-101 | Inhibitor | experimental | Small molecule | MET inhibitor |
| argx-111 | Inhibitor | experimental | mAb | MET inhibitor |
| arry-300 | Inhibitor | experimental | Small molecule | MET inhibitor |
| azd4144 | Inhibitor | experimental | Small molecule | MET inhibitor |
| azd9592 | Inhibitor | experimental | mAb | MET inhibitor |
| bg-c0902 | Inhibitor | experimental | mAb | MET inhibitor |
| bg-t187 | Inhibitor | experimental | Small molecule | MET inhibitor |
| bms-698769 | Inhibitor | experimental | Small molecule | MET inhibitor |
| bms-777607 | Inhibitor | experimental | Small molecule | MET inhibitor |
| bms-794833 | Inhibitor | experimental | Small molecule | MET inhibitor |
| bms-817378 | Inhibitor | experimental | Small molecule | MET inhibitor |
| bpi-9016 | Inhibitor | experimental | Small molecule | MET inhibitor |
| cabozantinib (cometriq) | Inhibitor | approved | Small molecule | MET inhibitor |
| capmatinib (Tabrecta) | Inhibitor | approved | Small molecule | MET inhibitor |
| cbt101 | Inhibitor | experimental | Cell therapy | MET inhibitor |
| ckd-702 | Inhibitor | experimental | mAb | MET inhibitor |
| crizotinib (xalkori) | Inhibitor | approved | Small molecule | MET inhibitor |
| dm005 | Inhibitor | experimental | mAb | MET inhibitor |
| do-2 | Inhibitor | experimental | Small molecule | MET inhibitor |
| Elzovantinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| emb-01 | Inhibitor | experimental | mAb | Hepatocyte growth factor receptor inhibitor |
| emd-1204831 | Inhibitor | experimental | Small molecule | MET inhibitor |
| emi-137 | Inhibitor | experimental | Small molecule | MET inhibitor |
| emibetuzumab | Inhibitor | experimental | mAb | MET inhibitor |
| foretinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| gb263t | Inhibitor | experimental | mAb | MET inhibitor |
| glesatinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| golvatinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| gst-hg161 | Inhibitor | experimental | Small molecule | MET inhibitor |
| gumarontinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| hlx55 | Inhibitor | experimental | mAb | MET inhibitor |
| hs-10241 | Inhibitor | experimental | Small molecule | MET inhibitor |
| hs-20117 | Inhibitor | experimental | mAb | MET inhibitor |
| hti-1066 | Inhibitor | experimental | mAb | MET inhibitor |
| jnj-38877605 | Inhibitor | experimental | Small molecule | MET inhibitor |
| jnj-38877618 | Inhibitor | experimental | Small molecule | MET inhibitor |
| jnj-88260237 | Inhibitor | experimental | Small molecule | MET inhibitor |
| kanitinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| kh617 | Inhibitor | experimental | Small molecule | MET inhibitor |
| ky-0301 | Inhibitor | experimental | mAb | MET inhibitor |
| lm-061 | Inhibitor | experimental | Small molecule | MET inhibitor |
| ly3164530 | Inhibitor | experimental | mAb | MET inhibitor |
| mdx2001 | Inhibitor | experimental | mAb | MET inhibitor |
| merestinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| metatinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| mgdc265 | Inhibitor | experimental | Small molecule | MET inhibitor |
| mhb042c | Inhibitor | experimental | mAb | MET inhibitor |
| mk-8033 | Inhibitor | experimental | Small molecule | MET inhibitor |
| mk2461 | Inhibitor | experimental | Small molecule | MET inhibitor |
| ningetinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| pf-04217903 | Inhibitor | experimental | Small molecule | MET inhibitor |
| plb1001 | Inhibitor | experimental | Small molecule | MET inhibitor |
| regn5093 | Inhibitor | experimental | mAb | MET inhibitor |
| sar-125844 | Inhibitor | experimental | Small molecule | MET inhibitor |
| savolitinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| sgx523 | Inhibitor | experimental | Small molecule | MET inhibitor |
| shr-a1403 | Inhibitor | experimental | mAb | MET inhibitor |
| sitravatinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| sph 3348 | Inhibitor | experimental | Small molecule | MET inhibitor |
| sym015 | Inhibitor | experimental | mAb | MET inhibitor |
| tas-115 | Inhibitor | experimental | Small molecule | MET inhibitor |
| tavo412 | Inhibitor | experimental | Small molecule | MET inhibitor |
| telisotuzumab vedodin (Emrelis) | Inhibitor | approved | mAb | MET inhibitor |
| tepotinib (Tepmetko) | Inhibitor | approved | Small molecule | MET inhibitor |
| tivantinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| tq-b3101 | Inhibitor | experimental | Small molecule | MET inhibitor |
| tqb6411 | Inhibitor | experimental | mAb | MET inhibitor |
| tr1801-adc | Inhibitor | experimental | mAb | MET inhibitor |
| utidelone | Inhibitor | experimental | Small molecule | MET inhibitor |
| vbc101 | Inhibitor | experimental | mAb | MET inhibitor |
| vert-002 | Inhibitor | experimental | Small molecule | MET inhibitor |
| volitinib | Inhibitor | experimental | Small molecule | MET inhibitor |
| xl092 | Inhibitor | experimental | Small molecule | MET inhibitor |