volitinib
Small moleculeexperimental
Savolitinib is an experimental small molecule inhibitor of c-Met. It is being investigated for the treatment of cancer by AstraZeneca. It is in phase II clinical trials for adenocarcinoma, non-small cell lung cancer, and renal cell carcinoma. It has been given conditional approval for these indication in China. — Wikipedia
Clinical trial activity
15 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
9
Phase 2
8
Phase 3
1
Phase 4
0
Earliest trial started Feb 1, 2012 (NCT01773018)
Timeline
Indications
Studied for
- Carcinoma · Phase 3
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Carcinoma, Renal Cell · Phase 3
- Colorectal Neoplasms · Phase 1
- Enzyme Inhibitors · Phase 3
- Health · Phase 1
- Kidney Diseases · Phase 3
- Kidney Neoplasms · Phase 3
- Lung Neoplasms · Phase 2
- Neoplasms · Phase 1
- Neoplasms by Site · Phase 3
- Pharmacology · Phase 1
- Protein Kinase Inhibitors · Phase 3
- Stomach Neoplasms · Phase 2
- Urologic Neoplasms · Phase 3
Mechanism of action
- Hepatocyte growth factor receptorINHIBITOR
MET inhibitor
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSavolitinib ↗
- ChEMBLCHEMBL3545336 ↗
Also known as
- 1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1h-pyrazol-4-yl)-1h-(1,2,3)triazolo(4,5-b)pyrazine
- azd6094
- azd6094
- azd6094
- azd-6094
- azd-6094
- hmpl-504
- hmpl-504
- hmpl-504
- savolitinib
- savolitinib
- savolitinib
- savolitinib
- volitinib
- volitinib
- volitinib
- volitinib
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03091192 | Phase 3 | May 17, 2017 | AstraZeneca, Harvard University, Hutchison MediPharma |
| NCT02447380 | Phase 2 | Mar 1, 2017 | Sungkyunkwan University |
| NCT02630420 | Phase 1 | Jan 1, 2017 | Yale University |
| NCT02897479 | Phase 2 | Oct 1, 2016 | Hutchison MediPharma, Jiao Tong University |
| NCT02819596 | Phase 1/Phase 2 (Phase 2) | May 1, 2016 | AstraZeneca, University of London |
| NCT02761057 | Phase 2 | Apr 5, 2016 | National Cancer Institute (NCI), Southwest Oncology Group |
| NCT02449551 | Phase 2 | Feb 10, 2016 | Sungkyunkwan University |
| NCT02447406 | Phase 1/Phase 2 (Phase 2) | Apr 30, 2015 | Sungkyunkwan University |
| NCT02374645 | Phase 1 | Apr 1, 2015 | AstraZeneca, Hutchison MediPharma, Shantou University |
| NCT02252913 | Phase 1 | Sep 1, 2014 | AstraZeneca, Fudan University, Hutchison MediPharma |
| NCT02143466 | Phase 1 | Aug 5, 2014 | AstraZeneca |
| NCT02127710 | Phase 2 | Apr 1, 2014 | AstraZeneca, SCRI Development Innovations |
| NCT02017236 | Phase 1 | Nov 1, 2013 | Hutchison MediPharma, Shanghai Xuhui District Central Hospital |
| NCT01985555 | Phase 1 | May 1, 2013 | Hutchison MediPharma |
| NCT01773018 | Phase 1 | Feb 1, 2012 | Hutchison MediPharma, Monash University, University of Melbourne, University of Washington, University of Western Australia |
Showing 15 of 15 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Hutchison MediPharma | For profit | 7 | 6 | 3 | 2012 |
| AstraZeneca | For profit | 6 | 3 | 3 | 2014 |
| Sungkyunkwan University | Academic/Hospital | 3 | 3 | 1 | 2015 |
| Fudan University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Jiao Tong University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Monash University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| National Cancer Institute (NCI) | Government | 1 | 1 | 1 | 2016 |
| SCRI Development Innovations | For profit | 1 | 0 | 1 | 2014 |
| Shanghai Xuhui District Central Hospital | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Shantou University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Southwest Oncology Group | Academic/Hospital | 1 | 0 | 1 | 2016 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Melbourne | Academic/Hospital | 1 | 0 | 1 | 2012 |
| University of Washington | Academic/Hospital | 1 | 0 | 1 | 2012 |
| University of Western Australia | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Yale University | Academic/Hospital | 1 | 1 | 1 | 2017 |
17 organizations
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