← Mechanisms of action
F2
SINGLE PROTEINHomo sapiens
Preferred name: Thrombin ChEMBL ↗
Linked proteins
Drugs acting on this target (37)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| human factor ix complex (prothrombin complex concentrate) (Bebulin) | Activator | approved | Biological | F2 activator |
| tp-508 | Activator | experimental | Peptide | F2 activator |
| defibrotide (defitelio) | Antagonist | approved | Animal product | Thrombin antagonist |
| hrs-7450 | Degrader | experimental | Recombinant protein | F2 degrader |
| human factor ix complex (prothrombin complex concentrate) (Bebulin) | Exogenous protein | approved | Biological | Thrombin exogenous protein |
| anti-inhibitor coagulant complex (activated prothrombin complex concentrate) (Autoplex-T) | Immunity, passive | approved | Biological | F2 immunity, passive |
| Antithrombin gamma | Inhibitor | experimental | Small molecule | F2 inhibitor |
| argatroban | Inhibitor | approved | Small molecule | F2 inhibitor |
| atecegatran metoxil | Inhibitor | experimental | Small molecule | Thrombin inhibitor |
| azd-0837 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| azd8165 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| bay 3389934 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| bay3389934 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| bibt 986 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| bivalirudin (angiomax) | Inhibitor | approved | Small molecule | F2 inhibitor |
| dabigatran (pradaxa) | Inhibitor | approved | Small molecule | F2 inhibitor |
| desirudin (Ipravask) | Inhibitor | approved | Biological | F2 inhibitor |
| dpoc-4088 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| gabexate | Inhibitor | experimental | Small molecule | F2 inhibitor |
| hht120 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| hirudin | Inhibitor | experimental | Biological | F2 inhibitor |
| jnj-64179375 | Inhibitor | experimental | mAb | F2 inhibitor |
| lepirudin (refludan) | Inhibitor | approved | Peptide | F2 inhibitor |
| mdco-2010 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| melagatran | Inhibitor | experimental | Small molecule | F2 inhibitor |
| thrombomodulin alfa | Inhibitor | experimental | Recombinant protein | F2 inhibitor |
| thromboview | Inhibitor | experimental | mAb | F2 inhibitor |
| uk-396,082 | Inhibitor | experimental | Small molecule | F2 inhibitor |
| unfractionated heparin | Inhibitor | experimental | Small molecule | F2 inhibitor |
| ximelagatran | Inhibitor | experimental | Small molecule | F2 inhibitor |
| apsac | Supplementation | experimental | Recombinant protein | F2 supplementation |
| e-we thrombin | Supplementation | experimental | Recombinant protein | F2 supplementation |
| medi8111 | Supplementation | experimental | Recombinant protein | F2 supplementation |
| polyethyleneglycol-hirudin | Supplementation | experimental | Recombinant protein | F2 supplementation |
| thrombin | Supplementation | experimental | Animal product | supplementation - thrombin |
| thrombin (human coagulation factor iia) (Evithrom) | Supplementation | approved | Biological | F2 supplementation |
| thrombin (porcine) | Supplementation | experimental | Animal product | F2 supplementation |