Esthesioneuroblastoma, Olfactory

A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)

Drugs by status

Phase 2 trials (6)

gemcitabine
cyclophosphamide
cisplatin
etoposide
bintrafusp alfa
tarlatamab

Phase 1 trials (1)

vmd-928

Organizations

Organization Involved with Phase 2 Indications (4)

National Cancer Institute (NCI)
Stanford University
University of Texas at Houston
University of Texas, San Antonio

Organization Involved with Phase 1 Indications (8)

Cancer and Leukemia Group B (CALGB)
Cornell University
Temple University
University of Virginia
University of Chicago
Vanderbilt University
State University of New York, Buffalo
Washington University in St. Louis

Organization Involved with Other Experimental Indications (1)

Southwest Oncology Group