Spasms, Infantile
An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
Drugs by status
Approved for this indication (4)
Phase 4 trials (1)
Phase 3 trials (4)
Phase 2 trials (5)
Phase 1 trials (1)
Other trials (1)
Organizations
Organization Involved with Phase 4 Indications (1)
Organization Involved with Phase 3 Indications (10)
Organization Involved with Phase 2 Indications (10)
- Marinus Pharmaceuticals
- National Center for Research Resources (NCRR)
- National Institute of Neurological Disorders and Stroke (NINDS)
- Dartmouth University
- Gillette Children's Specialty Healthcare
- Hoosier Cancer Research Network
- Northwestern University
- Mayo Clinic
- University of California, Los Angeles
- Bio-Pharm Solutions Co., Ltd.
Organization Involved with Other Experimental Indications (11)
- Orphelia Pharma SA
- Cook Children's Health Care System
- University of Pennsylvania
- Institut National de la Santé Et de la Recherche Médicale, France
- Queen Sirikit National Institute of Child Health
- University of Maryland
- University of Cincinnati
- Cook Children's Medical Center
- University of Lyon
- National Research Agency, France
- Thrasher Research Fund