125-iodine
Small moleculeexperimental
Iodide ion I-125 is radioisotope of iodine with half-life 59.4 days. It decays with the emission of low-energy gamma rays. It is used as a source for bone densitometry devices, protein iodination. Seeds implantations with I-125 are used in the clinics for the treatment of prostate cancer, malignant biliary obstruction, non-small cell lung cancer, colorectal cancer, uveal melanoma, and other tumors. — NCATS
Clinical trial activity
36 trials · 44 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
21
Phase 3
9
Phase 4
1
Earliest trial started Jul 1, 1990 (NCT00002802)
Timeline
Indications
Approved for
Studied for
- Brain Neoplasms · Phase 2
- Exophthalmos · Phase 3
- Graves Disease · Phase 3
- Head and Neck Neoplasms · Phase 1
- Hypothyroidism · Phase 3
- Lung Neoplasms · Phase 3
- Lymphoma, AIDS-Related · Phase 2
- Lymphoma, Large-Cell, Anaplastic · Phase 2
- Lymphoma, Non-Hodgkin · Phase 2
- Neoplasms · Phase 2
- Neuroblastoma · Phase 3
- Prostatic Neoplasms · Phase 3
- Retinoblastoma · Phase 3
- Sarcoma · Phase 2
- Thyroid Neoplasms · Phase 4
Mechanism of action
- Unspecified targetRadiodepletion
radiodepletion
Chemistry & pharmacology
Loading structure…
SMILES
[125I-]- Mol. weight
- 124.90462415 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaIsotopes of iodine ↗
- NCATSV1UJ6I93CL ↗
Also known as
- 125-iodine
- 125-iodine
- 131i
- 131i
- i131
- i131
- i-131
- i-131
- iodide-131
- iodide-131
- iodide i-131
- iodide i-131
- iodide i-131 ion
- iodide i-131 ion
- iodide ion i 131
- iodide ion i 131
- iodide ion, i-131
- iodide ion, i-131
- iodine-125
- iodine-125
- iodine 131
- iodine 131
- iodine-131
- iodine-131
- iodine i 125
- iodine i 125
- iodine i 131
- iodine i 131
- iodine i-131
- iodine i-131
- radioiodine
- radioiodine
- radioiodine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07277777 | Phase 2 | Dec 31, 2025 | People's Liberation Army of China |
| NCT04856852 | N/A | Jun 28, 2021 | Qingdao University |
| NCT04354324 | N/A | May 15, 2020 | Southern Medical University |
| NCT02565927 | Phase 2 | May 31, 2015 | Southeast University |
| NCT02393690 | Phase 2 | May 1, 2015 | Academic and Community Cancer Research United, National Cancer Institute (NCI) |
| NCT01704586 | N/A | May 1, 2015 | Deutsche Krebshilfe e.V., Julius-Maximilians University, University of Duisburg-Essen |
| NCT02152995 | Phase 2 | Aug 14, 2014 | Cornell University, National Cancer Institute (NCI) |
| NCT02418247 | Phase 2/Phase 3 (Phase 3) | May 1, 2013 | National Cancer Center, Korea |
| NCT02114619 | N/A | May 1, 2013 | Mashhad University of Medical Sciences |
| NCT01837745 | Phase 3 | Apr 1, 2013 | Institut Gustave Roussy |
| NCT01398085 | Phase 2/Phase 3 (Phase 3) | May 1, 2012 | Cancer Research UK, Newcastle University, University of London |
| NCT01579344 | N/A | Jan 1, 2012 | University of Sao Paulo |
| NCT01413113 | Phase 1 | Dec 1, 2011 | GlaxoSmithKline, National Cancer Institute (NCI), National Comprehensive Cancer Network, University of Washington |
| NCT01336894 | Phase 3 | May 1, 2011 | Boston University, National Cancer Institute (NCI) |
| NCT00902122 | Phase 4 | May 1, 2009 | Shenzhen SiBiono GeneTech Co.,Ltd, Sichuan University |
| NCT01098331 | N/A | May 1, 2009 | Moorgreen Hospital, Southampton, University of Leeds |
| NCT00389766 | Phase 2 | Jul 1, 2008 | Children's Cancer and Leukaemia Group, University of London |
| NCT01204359 | Phase 3 | Jul 1, 2007 | Sun Yat-Sen University |
| NCT00450411 | Phase 2 | May 1, 2007 | British Columbia Cancer Agency, National Cancer Institute (NCI), NRG Oncology, Radiation Therapy Oncology Group |
| NCT00416949 | N/A | Apr 1, 2006 | Johns Hopkins University, National Cancer Institute (NCI) |
Showing 20 of 36 trials
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Organizations
Research & Development (44)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 16 | 6 | 4 | 1997 |
| Radiation Therapy Oncology Group | Academic/Hospital | 5 | 5 | 2 | 1997 |
| Cornell University | Academic/Hospital | 2 | 1 | 1 | 1995 |
| GlaxoSmithKline | For profit | 2 | 1 | 2 | 1998 |
| Johns Hopkins University | Academic/Hospital | 2 | 1 | 2 | 2002 |
| NRG Oncology | Academic/Hospital | 2 | 0 | 2 | 2003 |
| University of Cincinnati | Academic/Hospital | 2 | 2 | 2 | 1990 |
| University of London | Academic/Hospital | 2 | 1 | 2 | 2008 |
| Wake Forest University | Academic/Hospital | 2 | 0 | 1 | 1999 |
| Academic and Community Cancer Research United | Academic/Hospital | 1 | 1 | 1 | 2015 |
| AIDS Malignancy Consortium | Academic/Hospital | 1 | 1 | 1 | 2006 |
| Bon Secours Cancer Institute | Academic/Hospital | 1 | 0 | 1 | 2003 |
| Boston University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Cancer Research UK | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Children's Cancer and Leukaemia Group | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Deutsche Krebshilfe e.V. | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Eastern Cooperative Oncology Group | Academic/Hospital | 1 | 0 | 1 | 1997 |
| Federal University of Rio Grande do Sul | Academic/Hospital | 1 | 1 | 1 | 1997 |
| Institut Gustave Roussy | Academic/Hospital | 1 | 1 | 1 | 2013 |
44 organizations
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