lactobacillus helveticus
Lactobacillus helveticus is a gram-positive, lactic-acid producing, rod-shaped bacterium of the genus Lactobacillus. It is most commonly used in the production of American Swiss cheese and Emmental cheese, but is also sometimes used in making other styles of cheese, such as Cheddar, Parmesan, Romano, provolone, and mozzarella. The primary function of L. helveticus culture is to prevent bitterness and produce nutty flavors in the final cheese. In Emmental cheese production, L. helveticus is used in conjunction with a Propionibacterium culture, which is responsible for developing the holes through production of carbon dioxide gas. — Wikipedia
Clinical trial activity
24 trials · 33 clinical orgs · 0 marketing orgs
Earliest trial started Dec 1, 2006 (NCT00655798)
Timeline
Indications
Approved for
Studied for
- Anxiety · Phase 4
- Attention Deficit Disorder with Hyperactivity · Phase 4
- Coronavirus Infections · Phase 2
- COVID-19 · Phase 2
- Depression · Phase 3
- Depressive Disorder · Phase 3
- Diarrhea · Phase 1/Phase 2
- Gastroenteritis · Phase 3
- Healthy Volunteers · Early Phase 1
- Liver Diseases, Alcoholic · Phase 4
- Major Depressive Disorder · Phase 3
- Metabolic Syndrome · Phase 3
- Non-alcoholic Fatty Liver Disease · Phase 3
- Obsessive-Compulsive Disorder · Phase 4
- Pneumonia, Viral · Phase 2
- Psychological Distress · Phase 3
- Stress, Psychological · Phase 3
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLactobacillus helveticus ↗
Also known as
- lactobacillus helveticus
- lactobacillus helveticus r0052
- l. helveticus r0052
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07165977 | N/A | Jan 25, 2024 | National Science Centre, Poland, SWPS University |
| NCT05567653 | N/A | Sep 21, 2022 | Poznan University |
| NCT04997057 | N/A | Sep 15, 2021 | CEN Biotech, Hopital Antoine Beclere, Pileje |
| NCT04784182 | N/A | Jul 20, 2021 | Auburn University, University of Alabama, Birmingham |
| NCT04756544 | Phase 3 | Dec 17, 2020 | Medical University of Lodz |
| NCT04366089 | Phase 2 | Mar 26, 2020 | University of Roma La Sapienza |
| NCT04555434 | N/A | Oct 1, 2019 | Hallym University |
| NCT04065503 | Early Phase 1 (Phase 1) | Sep 30, 2019 | Lallemand SAS, University of Florida |
| NCT03940612 | N/A | May 1, 2019 | Synbio Tech, University of Science Malaysia |
| NCT03801655 | N/A | Aug 15, 2018 | University of Oxford |
| NCT03277586 | Phase 3 | May 29, 2018 | Queen's University, Belfast |
| NCT02838043 | Phase 3 | Aug 1, 2016 | Lallemand SAS, McMaster University, Queen's University, Belfast |
| NCT02417454 | Phase 3 | Sep 1, 2015 | Lallemand SAS, McMaster University |
| NCT02545634 | Phase 4 | Jun 1, 2015 | Acadia University, Lallemand SAS |
| NCT02334644 | Phase 4 | Apr 1, 2015 | Hamilton Health Sciences Corporation, Lallemand SAS, McMaster University |
| NCT02215304 | N/A | Jun 1, 2014 | Lallemand SAS, ProbiSearch SL, Universidad Autonoma de Madrid |
| NCT01853124 | Phase 3 | Nov 1, 2013 | Canadian Institutes of Health Research (CIHR), Dalhousie University, Lallemand SAS, University of Calgary, University of Montreal, University of Ottawa, University of Toronto, University of Western Ontario |
| NCT01941160 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2013 | KGK Science Inc., Lallemand SAS |
| NCT02335632 | Phase 4 | Dec 1, 2012 | Hallym University |
| NCT01709825 | N/A | Sep 1, 2012 | Lallemand SAS, University of Florida |
Organizations
Research & Development (33)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Lallemand SAS | For profit | 11 | 2 | 5 | 2008 |
| McMaster University | Academic/Hospital | 3 | 2 | 2 | 2015 |
| Hallym University | Academic/Hospital | 2 | 2 | 2 | 2012 |
| Queen's University, Belfast | Academic/Hospital | 2 | 2 | 1 | 2016 |
| University of Florida | Academic/Hospital | 2 | 2 | 2 | 2012 |
| University of Toronto | Academic/Hospital | 2 | 1 | 2 | 2009 |
| Acadia University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Auburn University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Biofortis | For profit | 1 | 0 | 1 | 2008 |
| Canadian Institutes of Health Research (CIHR) | Academic/Hospital | 1 | 0 | 1 | 2013 |
| CEN Biotech | For profit | 1 | 1 | 1 | 2021 |
| Chr Hansen | For profit | 1 | 0 | 1 | 2006 |
| Dalhousie University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Hamilton Health Sciences Corporation | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Hopital Antoine Beclere | Academic/Hospital | 1 | 0 | 1 | 2021 |
| KGK Science Inc. | For profit | 1 | 1 | 1 | 2013 |
| Medical University of Lodz | Academic/Hospital | 1 | 1 | 1 | 2020 |
| National Science Centre, Poland | Government | 1 | 0 | 1 | 2024 |
| Pileje | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Poznan University | Academic/Hospital | 1 | 1 | 1 | 2022 |