pegunigalsidase alfa

Trade name: Elfabrio

Recombinant proteinapprovedFast Track FDA

Approved

May 9, 2023

Clinical trial activity

12 trials · 4 clinical orgs · 1 marketing orgs

Phase 1
3
Phase 2
9
Phase 3
8
Phase 4
0

Earliest trial started Oct 1, 2012 (NCT01678898)

Timeline

2010s

  1. Jan 1, 2012

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2016

    Earliest Phase 3 Sponsor(trial)

2020s

  1. Jan 1, 2023

    Chiesi — Earliest Phase 2 Sponsor(trial)

  2. May 9, 2023

    Chiesi — Earliest FDA Approval

  3. May 9, 2023

    Chiesi — Marketing Organization

  4. May 9, 2023

    Chiesi — NDA Secondary Org

  5. May 9, 2023

    Chiesi — NDA Organization

Indications

Mechanism of action

Approval history

  • approvedPriority reviewFast trackMay 9, 2023

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Availability
Prescription Only
Multi-specific
No

Oral

No

Parenteral

No

Topical

No

Black box warning

Sources

Also known as

  • pegunigalsidase alfa
  • pegunigalsidase alfa
  • prx-102
  • prx-102

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06328608Phase 2/Phase 3 (Phase 3)Oct 31, 2024Chiesi, ICON
NCT05710692Phase 2/Phase 3 (Phase 3)Aug 1, 2023Chiesi, ICON
NCT03614234Phase 3Nov 30, 2018Protalix
NCT03566017Phase 3Sep 30, 2018Protalix
NCT03180840Phase 3Dec 1, 2017Protalix
NCT02921620Phase 3Jul 1, 2017Protalix
NCT03018730Phase 3Feb 23, 2017Protalix
NCT02795676Phase 3Jun 1, 2016Protalix
NCT01981720Phase 1/Phase 2 (Phase 2)Dec 1, 2013Protalix
NCT01769001Phase 1/Phase 2 (Phase 2)Mar 1, 2013Protalix
NCT01678898Phase 1/Phase 2 (Phase 2)Oct 1, 2012Protalix
NCT04552691N/AChiesi, Covance, Protalix
Showing 12 of 12 trials
Page 1 / 1

Organizations

Research & Development (4)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
ProtalixFor profit101032012
ChiesiFor profit3222023
ICONFor profit2012023
CovanceFor profit101
4 organizations
Page 1 / 1

Marketing (3)

OrganizationOrg typeRelationshipDate
ChiesiFor profitMKTGMay 9, 2023
ChiesiFor profitNDA2May 9, 2023
ChiesiFor profitNDAMay 9, 2023