← Mechanisms of action
GLA
SINGLE PROTEINHomo sapiens
Preferred name: Alpha-galactosidase A ChEMBL ↗
Linked proteins
Drugs acting on this target (13)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| agalsidase alfa (Replagal) | Activator | experimental | Recombinant protein | GLA activator |
| agalsidase beta (Fabrazyme) | Activator | approved | Recombinant protein | GLA activator |
| migalastat (galafold) | Stabiliser | approved | Small molecule | GLA stabiliser |
| 4d-310 | Supplementation | experimental | Gene therapy | GLA supplementation |
| agalsidase alfa (Replagal) | Supplementation | experimental | Recombinant protein | GLA supplementation |
| agalsidase beta (Fabrazyme) | Supplementation | approved | Recombinant protein | GLA supplementation |
| amt-191 | Supplementation | experimental | Gene therapy | GLA supplementation |
| bbm-f101 | Supplementation | experimental | Gene therapy | GLA supplementation |
| exg110 | Supplementation | experimental | Gene therapy | GLA supplementation |
| exg202 | Supplementation | experimental | Gene therapy | GLA supplementation |
| hm15421 | Supplementation | experimental | Biologics | GLA supplementation |
| pegunigalsidase alfa (Elfabrio) | Supplementation | approved | Recombinant protein | GLA supplementation |
| st-920 | Supplementation | experimental | Gene therapy | supplementation - GLA |