irradiated donor lymphocyte
Cell therapyexperimental
Clinical trial activity
6 trials · 14 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
3
Phase 3
0
Phase 4
1
Earliest trial started Jul 1, 2006 (NCT00810810)
Timeline
Indications
Approved for
Studied for
- Blood Component Transfusion · Phase 4
- Chromosome Aberrations · Phase 2
- Hematopoietic Stem Cell Transplantation · Phase 2
- Leukemia · Phase 1
- Leukemia, Myeloid, Acute · Phase 2
- Lymphoma · Phase 1
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Mantle-Cell · Phase 2
- Lymphoma, Non-Hodgkin · Phase 2
- Melanoma · Phase 2
- Multiple Myeloma · Phase 2
- Mutation · Phase 2
- Myelodysplastic Syndromes · Phase 2
- Neoplasm, Residual · Phase 2
- Neoplasms · Phase 2
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 2
Mechanism of action
- LymphocytesImmunity, passive
Lymphocytes immunity, passive
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- irradiated blood cell
- irradiated donor-derived lymphoblastoid cell line
- irradiated donor lymphocyte
- irradiated haploidentical allogeneic lymphocytes
- leukoreduced and irradiated blood cells
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03272633 | Phase 2 | Jul 1, 2018 | National Cancer Institute (NCI), Rutgers University |
| NCT01925118 | Phase 2 | Aug 1, 2013 | Seoul National University |
| NCT01195480 | Phase 1/Phase 2 (Phase 2) | May 1, 2012 | Department of Health, United Kingdom, Deutsche Krebshilfe e.V., European Union, JP Moulton Charitable Foundation, The Leukemia and Lymphoma Society, University of London |
| NCT00996359 | Phase 1 | Oct 1, 2009 | National Cancer Institute (NCI), Rutgers University, University of Medicine and Dentistry of New Jersey |
| NCT00693498 | N/A | Jul 1, 2008 | University of Rochester |
| NCT00810810 | Phase 4 | Jul 1, 2006 | National Heart, Lung, and Blood Institute (NHLBI), Puget Sound Blood Center, University of Washington |
Showing 6 of 6 trials
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Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 2 | 0 | 2 | 2009 |
| Rutgers University | Academic/Hospital | 2 | 1 | 2 | 2009 |
| Department of Health, United Kingdom | Government | 1 | 0 | 1 | 2012 |
| Deutsche Krebshilfe e.V. | Academic/Hospital | 1 | 0 | 1 | 2012 |
| European Union | Government | 1 | 0 | 1 | 2012 |
| JP Moulton Charitable Foundation | Academic/Hospital | 1 | 0 | 1 | 2012 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2006 |
| Puget Sound Blood Center | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Seoul National University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| The Leukemia and Lymphoma Society | Academic/Hospital | 1 | 0 | 1 | 2012 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of Medicine and Dentistry of New Jersey | Academic/Hospital | 1 | 1 | 1 | 2009 |
| University of Rochester | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Washington | Academic/Hospital | 1 | 1 | 1 | 2006 |
14 organizations
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