cabiralizumab
Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved in cancer-related inflammation. Macrophages are known to originate from bone marrow-derived blood monocytes or yolk sac progenitors, but the exact origin of TAMs in human tumors remains to be elucidated. The composition of monocyte-derived macrophages and tissue-resident macrophages in the tumor microenvironment depends on the tumor type, stage, size, and location, thus it has been proposed that TAM identity and heterogeneity is the outcome of interactions between tumor-derived, tissue-specific, and developmental signals. — Wikipedia
Clinical trial activity
15 trials · 14 clinical orgs · 0 marketing orgs
Earliest trial started Oct 1, 2013 (NCT01962337)
Timeline
Indications
Studied for
- Arthritis, Rheumatoid · Phase 1
- Biliary Tract Neoplasms · Phase 2
- Carcinoma, Hepatocellular · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Carcinoma, Renal Cell · Phase 1
- Giant Cell Tumor of Tendon Sheath · Phase 1/Phase 2
- Glioma · Phase 1
- Head and Neck Neoplasms · Phase 1
- Healthy Volunteers · Phase 1
- Lymphoma · Phase 1
- Lymphoma, T-Cell, Peripheral · Phase 2
- Melanoma · Phase 1
- Neoplasms · Phase 1
- Ovarian Neoplasms · Phase 1
- Pancreatic Neoplasms · Phase 2
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Synovitis, Pigmented Villonodular · Phase 1/Phase 2
- Triple Negative Breast Neoplasms · Phase 1/Phase 2
Mechanism of action
Macrophage colony stimulating factor receptor antagonist
CSF1R inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTumor-associated macrophage ↗
- ChEMBLCHEMBL4297713 ↗
Also known as
- cabiralizumab
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04848116 | Phase 2 | Apr 24, 2021 | Bristol-Myers Squibb, Johns Hopkins University |
| NCT04331067 | Phase 1/Phase 2 (Phase 2) | Jun 30, 2020 | Bristol-Myers Squibb, Washington University in St. Louis |
| NCT03697564 | Phase 2 | Sep 30, 2019 | Stand Up To Cancer, University of California, San Diego |
| NCT04050462 | Phase 2 | Aug 26, 2019 | New York University |
| NCT03768531 | Phase 2 | Jun 30, 2019 | Bristol-Myers Squibb, Johns Hopkins University |
| NCT03927105 | Phase 2 | May 31, 2019 | Big Ten Cancer Research Consortium, Bristol-Myers Squibb, University of Michigan |
| NCT03599362 | Phase 2 | Aug 31, 2018 | New York University |
| NCT03502330 | Phase 1 | Jun 9, 2018 | Apexigen, Inc., Bristol-Myers Squibb, National Cancer Institute (NCI), Yale University |
| NCT03431948 | Phase 1 | Mar 15, 2018 | Bristol-Myers Squibb, University of Chicago |
| NCT03335540 | Phase 1 | Mar 13, 2018 | Bristol-Myers Squibb |
| NCT03336216 | Phase 2 | Dec 15, 2017 | Bristol-Myers Squibb |
| NCT03158272 | Phase 1 | Jun 16, 2017 | Bristol-Myers Squibb, Ono Pharmaceuticals |
| NCT02526017 | Phase 1 | Sep 1, 2015 | Bristol-Myers Squibb, Five Prime Therapeutics |
| NCT02471716 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2015 | Five Prime Therapeutics |
| NCT01962337 | Phase 1 | Oct 1, 2013 | Five Prime Therapeutics |
Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bristol-Myers Squibb | For profit | 10 | 3 | 2 | 2015 |
| Five Prime Therapeutics | For profit | 3 | 3 | 2 | 2013 |
| Johns Hopkins University | Academic/Hospital | 2 | 2 | 1 | 2019 |
| New York University | Academic/Hospital | 2 | 2 | 1 | 2018 |
| Apexigen, Inc. | For profit | 1 | 0 | 1 | 2018 |
| Big Ten Cancer Research Consortium | Academic/Hospital | 1 | 1 | 1 | 2019 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2018 |
| Ono Pharmaceuticals | For profit | 1 | 0 | 1 | 2017 |
| Stand Up To Cancer | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of California, San Diego | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Chicago | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Michigan | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Washington University in St. Louis | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Yale University | Academic/Hospital | 1 | 1 | 1 | 2018 |