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aramchol

Small moleculeexperimental

Aramchol is an investigational drug being developed by Galmed Pharmaceuticals as a first-in-class, potentially treatment for nonalcoholic steatohepatitis,(NASH), a progressive form of non-alcoholic fatty liver disease. — Wikipedia

Clinical trial activity

15 trials · 25 clinical orgs · 0 marketing orgs

Phase 1
9
Phase 2
5
Phase 3
2
Phase 4
0

Earliest trial started Sep 1, 2008 (NCT00776841)

Timeline

2000s

  1. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2010

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2019

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCCCCCCCCCCCCCCCCCCC(=O)N[C@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](O)[C@@H]1[C@@H]2C[C@H](O)[C@]2(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]12.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Mol. weight
897.33 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • arachidyl amido cholanoic acid
  • aramchol
  • aramchol
  • aramchol
  • aramchol

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07251712Phase 1Dec 25, 2025Galmed Pharmaceuticals Ltd, Hammersmith Medicines Research
NCT06502561Phase 1Oct 31, 2024Galmed Pharmaceuticals Ltd
NCT06095986Phase 2Jun 30, 2024Galmed Pharmaceuticals Ltd, Virginia Commonwealth University
NCT05874336Phase 1Jun 17, 2020Galmed Pharmaceuticals Ltd, Quotient
NCT04480827Phase 1Jan 22, 2020Galmed Pharmaceuticals Ltd
NCT04104321Phase 3Sep 30, 2019Galmed Pharmaceuticals Ltd
NCT03774173Phase 1Dec 8, 2018Analyst Research Laboratories Ltd., Diamond Pharma Services, Galmed Pharmaceuticals Ltd, Hammersmith Medicines Research
NCT03760848Phase 1Nov 12, 2018Alderley Analytical, Analyst Research Laboratories Ltd., Diamond Pharma Services, Galmed Pharmaceuticals Ltd, Hammersmith Medicines Research
NCT02803996Phase 1May 1, 2016Alpha IRB, Analyst Research Laboratories Ltd., Diamond Pharma Services, Galmed Pharmaceuticals Ltd, Synergy Partners, WCCT Global
NCT02684591Phase 2Jan 1, 2016University of California, San Diego
NCT02279524Phase 2/Phase 3 (Phase 3)Jan 1, 2015ClinIntel, Diamond Pharma Services, Galmed Pharmaceuticals Ltd, Itamar-Medical, Israel, Medical University of Graz, Sharp Clinical Services, Tel Aviv University, TransPerfect, University of Milan
NCT02325492Phase 2Oct 1, 2014Ben Gurion University, Galmed Pharmaceuticals Ltd
NCT02374437Phase 1Apr 1, 2014Galmed Pharmaceuticals Ltd
NCT01094158Phase 2Nov 1, 2010Bar Ilan University, Beilinson Hospital, Petach Tikva, Ben Gurion University, Galmed Pharmaceuticals Ltd, Hebrew University, Hillel Yaffe Medical Center, Holy Family Hospital, Nazareth, Israel, Technion University, Tel Aviv University
NCT00776841Phase 1Sep 1, 2008Galmed Pharmaceuticals Ltd, Tel Aviv University
Showing 15 of 15 trials
Page 1 / 1

Organizations

Research & Development (25)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Galmed Pharmaceuticals LtdFor profit141432008
Diamond Pharma ServicesFor profit4022015
Analyst Research Laboratories Ltd.For profit3012016
Hammersmith Medicines ResearchFor profit3012018
Tel Aviv UniversityAcademic/Hospital3032008
Ben Gurion UniversityAcademic/Hospital2012010
Alderley AnalyticalFor profit1012018
Alpha IRBFor profit1012016
Bar Ilan UniversityAcademic/Hospital1012010
Beilinson Hospital, Petach TikvaAcademic/Hospital1012010
ClinIntelFor profit1012015
Hebrew UniversityAcademic/Hospital1012010
Hillel Yaffe Medical CenterAcademic/Hospital1012010
Holy Family Hospital, Nazareth, IsraelAcademic/Hospital1012010
Itamar-Medical, IsraelFor profit1012015
Medical University of GrazAcademic/Hospital1012015
QuotientFor profit1012020
Sharp Clinical ServicesFor profit1012015
Synergy PartnersFor profit1012016
Technion UniversityAcademic/Hospital1012010
25 organizations
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