as03
Small moleculeexperimental
Clinical trial activity
29 trials · 28 clinical orgs · 0 marketing orgs
Phase 1
12
Phase 2
20
Phase 3
3
Phase 4
1
Earliest trial started Aug 20, 2009 (NCT00964951)
Timeline
Indications
Approved for
Studied for
- Allergy and Immunology · Phase 4
- COVID-19 · Phase 3
- Dengue · Phase 1
- Graft Rejection · Phase 4
- Healthy Volunteers · Phase 1/Phase 2
- Hepatitis B · Phase 1/Phase 2
- Influenza A Virus, H1N1 Subtype · Phase 3
- Influenza A Virus, H5N1 Subtype · Phase 2
- Influenza A Virus, H7N9 Subtype · Phase 1
- Influenza, Human · Phase 4
- Influenza in Birds · Phase 2
- Klebsiella pneumoniae · Phase 1/Phase 2
- Lymphoma · Phase 3
- Multiple Myeloma · Phase 3
- Vaccines · Phase 1
Mechanism of action
- Toll-like receptor 4ACTIVATOR
TLR4 activator
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- as03
- as03
- as03b
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06560151 | Phase 2 | Aug 21, 2024 | Department of Health and Human Services, ICON, Rho, Inc. |
| NCT05975840 | Phase 1/Phase 2 (Phase 2) | Aug 3, 2023 | GlaxoSmithKline |
| NCT05501522 | Phase 3 | Nov 30, 2022 | Coalition for Epidemic Preparedness Innovations, GlaxoSmithKline, International Vaccine Institute, SK Bioscience Co., Ltd. |
| NCT05561673 | Phase 1/Phase 2 (Phase 2) | Oct 4, 2022 | GlaxoSmithKline |
| NCT05289037 | Phase 1/Phase 2 (Phase 2) | Mar 30, 2022 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT04959344 | Phase 1/Phase 2 (Phase 2) | Jul 5, 2021 | GlaxoSmithKline, LimmaTech Biologics AG, Nuvisan Pharma Services |
| NCT04789577 | Phase 2 | Mar 16, 2021 | GlaxoSmithKline |
| NCT04750343 | Phase 1/Phase 2 (Phase 2) | Feb 3, 2021 | Coalition for Epidemic Preparedness Innovations, GlaxoSmithKline, Korea University, SK Bioscience Co., Ltd. |
| NCT04672395 | Phase 2/Phase 3 (Phase 3) | Dec 31, 2020 | Clover Biopharmaceuticals, Coalition for Epidemic Preparedness Innovations, International Vaccine Institute |
| NCT04662697 | Phase 2 | Dec 11, 2020 | Medicago |
| NCT04405908 | Phase 1 | Jun 20, 2020 | Clover Biopharmaceuticals |
| NCT03738241 | Phase 2 | Dec 18, 2018 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT03589807 | Phase 2 | Aug 14, 2018 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT03497845 | Phase 2 | Mar 15, 2018 | Department of Health and Human Services |
| NCT03318315 | Phase 2 | Feb 20, 2018 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT03312231 | Phase 2 | Feb 14, 2018 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT03300050 | Phase 1 | Oct 10, 2017 | Duke University, GlaxoSmithKline, Icahn School of Medicine at Mount Sinai, PATH, The EMMES Corporation, University of Cincinnati |
| NCT03283319 | Phase 2 | Sep 20, 2017 | Central Kentucky Research Assoc, Inc, Department of Health and Human Services, Heartland Research Associates, LLC, Johnson County Clin-Trials, Rho, Inc., Rochester Clinical Research |
| NCT03014310 | Phase 1 | Jan 17, 2017 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT02957656 | Phase 1 | Dec 1, 2016 | National Institute of Allergy and Infectious Diseases (NIAID), University of Rochester |
Showing 20 of 29 trials
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Organizations
Research & Development (28)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 13 | 13 | 2 | 2009 |
| GlaxoSmithKline | For profit | 8 | 3 | 3 | 2012 |
| Coalition for Epidemic Preparedness Innovations | Academic/Hospital | 3 | 0 | 2 | 2020 |
| Department of Health and Human Services | Government | 3 | 3 | 1 | 2017 |
| Clover Biopharmaceuticals | For profit | 2 | 2 | 2 | 2020 |
| International Vaccine Institute | Academic/Hospital | 2 | 0 | 1 | 2020 |
| Rho, Inc. | For profit | 2 | 0 | 1 | 2017 |
| SK Bioscience Co., Ltd. | For profit | 2 | 2 | 2 | 2021 |
| Central Kentucky Research Assoc, Inc | For profit | 1 | 0 | 1 | 2017 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Erasmus University Rotterdam | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Free University of Brussels | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Heartland Research Associates, LLC | For profit | 1 | 0 | 1 | 2017 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 0 | 1 | 2017 |
| ICON | For profit | 1 | 0 | 1 | 2024 |
| Johnson County Clin-Trials | For profit | 1 | 0 | 1 | 2017 |
| Korea University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| LimmaTech Biologics AG | For profit | 1 | 1 | 1 | 2021 |
| Medicago | For profit | 1 | 1 | 1 | 2020 |
| Nuvisan Pharma Services | For profit | 1 | 0 | 1 | 2021 |
28 organizations
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