apg-115
Small moleculeexperimental
Clinical trial activity
8 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2016 (NCT02935907)
Timeline
Indications
Studied for
- Carcinoma, Non-Small-Cell Lung · Phase 1/Phase 2
- Carcinoma, Transitional Cell · Phase 1/Phase 2
- Leukemia, Myeloid, Acute · Phase 1
- Leukemia, Myelomonocytic, Chronic · Phase 1
- Liposarcoma · Phase 1/Phase 2
- Melanoma · Phase 1/Phase 2
- Mesothelioma · Phase 2
- Mutation · Phase 2
- Myelodysplastic Syndromes · Phase 1
- Neoplasms · Phase 2
- Nerve Sheath Neoplasms · Phase 1/Phase 2
- Neuroblastoma · Phase 1
- Neurofibroma · Phase 1/Phase 2
- Neurofibromatosis 1 · Phase 1/Phase 2
- Neurofibrosarcoma · Phase 1/Phase 2
Mechanism of action
- E3 ubiquitin-protein ligase Mdm2INHIBITOR
MDM2 inhibitor
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- apg-115
- apg-115
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06735820 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2025 | Georgetown University |
| NCT06654050 | Phase 2 | Nov 17, 2024 | National Cancer Institute (NCI) |
| NCT05701306 | Phase 1 | Mar 23, 2023 | Ascentage Pharma Group Inc., Government of China, Sun Yat-Sen University |
| NCT04785196 | Phase 1/Phase 2 (Phase 2) | Jun 2, 2021 | Ascentage Pharma Group Inc., Government of China, Huazhong University of Science and Technology |
| NCT04358393 | Phase 1 | Jun 1, 2020 | Ascentage Pharma Group Inc. |
| NCT04275518 | Phase 1 | Feb 29, 2020 | Ascentage Pharma Group Inc., Chinese Academy of Medical Sciences |
| NCT03611868 | Phase 1/Phase 2 (Phase 2) | Sep 15, 2018 | Ascentage Pharma Group Inc. |
| NCT02935907 | Phase 1 | Oct 1, 2016 | Ascentage Pharma Group Inc., South Texas Accelerated Research Therapeutics |
Showing 8 of 8 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ascentage Pharma Group Inc. | For profit | 6 | 6 | 2 | 2016 |
| Government of China | Government | 2 | 0 | 2 | 2021 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Georgetown University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 0 | 1 | 2021 |
| National Cancer Institute (NCI) | Government | 1 | 1 | 1 | 2024 |
| South Texas Accelerated Research Therapeutics | For profit | 1 | 0 | 1 | 2016 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 0 | 1 | 2023 |
8 organizations
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