zibotentan
Small moleculeexperimental
Zibotentan is an experimental anti-cancer drug candidate in development by AstraZeneca. It is an endothelin receptor antagonist. — Wikipedia
Clinical trial activity
32 trials · 26 clinical orgs · 0 marketing orgs
Phase 1
11
Phase 2
20
Phase 3
4
Phase 4
0
Earliest trial started Jun 1, 2003 (NCT00055471)
Timeline
Indications
Studied for
- Breast Neoplasms · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Colorectal Neoplasms · Phase 2
- Healthy Volunteers · Phase 1
- Intermittent Claudication · Phase 2
- Kidney Failure, Chronic · Phase 3
- Liver Cirrhosis · Phase 2
- Liver Diseases · Phase 1
- Lung Neoplasms · Phase 2
- Microvascular Angina · Phase 2
- Neoplasm Metastasis · Phase 2
- Neoplasms · Phase 1
- Ovarian Neoplasms · Phase 2
- Peripheral Arterial Disease · Phase 2
- Prostatic Neoplasms · Phase 3
- Renal Insufficiency, Chronic · Phase 2
- Scleroderma, Systemic · Phase 2
Mechanism of action
- Endothelin receptor ET-AANTAGONIST
EDNRA antagonist
Chemistry & pharmacology
Loading structure…
SMILES
COc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(-c2nnco2)cc1- Mol. weight
- 424.44 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaZibotentan ↗
- ChEMBLCHEMBL1628688 ↗
Also known as
- trans,trans-2(4-methoxyphenyl)-4-(1-3-benzodiazol-5-yl)-1-(dibutylaminocarbonylmethyl)pyrrolidine-3-carboxylic acid
- zd4054
- zd-4054
- zd-4054
- zibotentan
- zibotentan
- zibotentan
- zibotentan
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06942910 | Phase 2 | May 7, 2025 | AstraZeneca |
| NCT06715670 | Phase 1 | Dec 2, 2024 | AstraZeneca, Parexel |
| NCT06269484 | Phase 2 | Feb 15, 2024 | AstraZeneca |
| NCT06087835 | Phase 3 | Nov 7, 2023 | AstraZeneca |
| NCT05516498 | Phase 2 | Oct 31, 2022 | AstraZeneca |
| NCT05570305 | Phase 2 | Oct 6, 2022 | AstraZeneca, University of Groningen |
| NCT05505162 | Phase 1 | Aug 24, 2022 | AstraZeneca, Parexel |
| NCT05112419 | Phase 1 | Nov 10, 2021 | AstraZeneca |
| NCT04991571 | Phase 1 | Jul 29, 2021 | AstraZeneca |
| NCT04724837 | Phase 2 | Apr 28, 2021 | AstraZeneca, University College London, Vanderbilt University |
| NCT04097314 | Phase 2 | Nov 1, 2019 | University of Glasgow |
| NCT02047708 | Phase 2 | Oct 1, 2014 | Medical Research Council, University of London |
| NCT01890135 | Phase 2 | Jun 1, 2013 | National Institutes of Health (NIH), University of Virginia |
| NCT01134497 | Phase 2 | Sep 1, 2010 | Cardiff University |
| NCT01119118 | Phase 2 | Apr 1, 2010 | AstraZeneca, University of Wisconsin |
| NCT01205711 | Phase 2 | Apr 1, 2010 | Cardiff University, University of Leicester |
| NCT00997945 | Phase 1 | Oct 1, 2009 | AstraZeneca, Fudan University |
| NCT01000948 | Phase 2 | Oct 1, 2009 | Aarhus University, University of Copenhagen |
| NCT01168141 | N/A | Jul 1, 2009 | AstraZeneca, The Christie NHS Foundation Trust |
| NCT00929162 | Phase 2 | Jun 1, 2009 | AstraZeneca, ISTITUTO REGINA ELENA |
Showing 20 of 32 trials
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Organizations
Research & Development (26)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| AstraZeneca | For profit | 26 | 23 | 4 | 2003 |
| Parexel | For profit | 4 | 0 | 1 | 2008 |
| Cardiff University | Academic/Hospital | 2 | 2 | 1 | 2010 |
| Aarhus University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Fudan University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Humboldt University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Institut Gustave Roussy | Academic/Hospital | 1 | 0 | 1 | 2008 |
| ISTITUTO REGINA ELENA | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Medical Research Council | Government | 1 | 0 | 1 | 2014 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2013 |
| Pharmaceutical Research Associates, Inc. (PRA) | For profit | 1 | 0 | 1 | 2008 |
| The Christie NHS Foundation Trust | Academic/Hospital | 1 | 1 | 1 | 2009 |
| University College London | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of British Columbia | Academic/Hospital | 1 | 0 | 1 | 2007 |
| University of Copenhagen | Academic/Hospital | 1 | 0 | 1 | 2009 |
| University of Glasgow | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Groningen | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Leicester | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2014 |
26 organizations
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