dianhydrogalactitol
Small moleculeexperimental
Clinical trial activity
5 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2011 (NCT01478178)
Timeline
Indications
Mechanism of action
- DNACROSS-LINKING AGENT
DNA cross-linking agent
Chemistry & pharmacology
Loading structure…
SMILES
O[C@H]([C@H](O)[C@@H]1CO1)[C@H]1CO1- Mol. weight
- 146.14 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3137322 ↗
Also known as
- dianhydrogalactitol
- dianhydrogalactitol
- dianhydrogalactitol
- nsc-1323313
- nsc-1323313
- val-083
- val-083
- val-083
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03281681 | Phase 1/Phase 2 (Phase 2) | Jun 30, 2018 | Kintara Therapeutics, Inc., St. Joseph's Hospital and Medical Center - Phoenix, Arizona |
| NCT03050736 | Phase 2 | Jun 1, 2017 | Kintara Therapeutics, Inc., Sun Yat-Sen University |
| NCT03138629 | N/A | May 1, 2017 | Kintara Therapeutics, Inc. |
| NCT02717962 | Phase 2 | Jan 20, 2017 | Kintara Therapeutics, Inc., University of Texas at Houston |
| NCT01478178 | Phase 1/Phase 2 (Phase 2) | Oct 1, 2011 | Florida Cancer Specialists, Sarasota, Kintara Therapeutics, Inc., Mayo Clinic, SCRI Development Innovations, University of California, San Francisco |
Showing 5 of 5 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Kintara Therapeutics, Inc. | For profit | 5 | 5 | 2 | 2011 |
| Florida Cancer Specialists, Sarasota | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2011 |
| SCRI Development Innovations | For profit | 1 | 0 | 1 | 2011 |
| St. Joseph's Hospital and Medical Center - Phoenix, Arizona | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of California, San Francisco | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2017 |
8 organizations
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