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rupatadine

Small moleculeexperimental

Rupatadine is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies. It was discovered and developed by Uriach and is marketed as Rupafin and under several other trade names. — Wikipedia

Clinical trial activity

15 trials · 19 clinical orgs · 0 marketing orgs

Phase 1
4
Phase 2
6
Phase 3
4
Phase 4
3

Earliest trial started Oct 1, 2002 (NCT00199238)

Timeline

2000s

  1. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2004

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

Cc1cncc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1
Mol. weight
415.97 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Oral

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • 8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridinyl)methyl)-4-piperidinylidene)-5h-benzo(5,6)cyclohepta(1,2-b)pyridine
  • alergoliber
  • pafinur
  • rinialer
  • rupafin
  • rupatadine
  • rupatadine
  • rupatadine
  • rupatadine
  • rupatadine
  • rupatadine
  • rupatadine
  • rupatadine
  • rupax
  • ur 12592
  • ur-12592

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07064707Phase 2Jul 15, 2025Alexandria University, Kafrelsheikh University
NCT06709092N/AMar 1, 2024Nanjing Medical University
NCT06708520Phase 1Nov 21, 2022Badalona Hospital Germans Trias i Pujol, Blueclinical Investigacao E Desenvolvimento Em Saude Lda., Centro Hospitalar de Vila Nova de Gaia/Espinho, Hospital Pedro Hispano, Noucor Health S.A., Universidad Autonoma de Madrid, University of Barcelona
NCT06736340Phase 1Nov 17, 2022Autonomous University of Madrid, Blueclinical Investigacao E Desenvolvimento Em Saude Lda., Centro Hospitalar de Vila Nova de Gaia/Espinho, Hospital Pedro Hispano, Noucor Health S.A., Universidad Autonoma de Madrid, Universidad Complutense de Madrid, University of Barcelona
NCT05356143Phase 1Dec 2, 2021J. Uriach and Company
NCT04601324Phase 4Dec 15, 2020St. Paul's Sinus Centre
NCT03770923Phase 3Oct 1, 2018Tanta University
NCT02358265Phase 3Dec 1, 2014Humboldt University
NCT01605487Phase 2Jun 1, 2012Humboldt University, Universidad Autonoma de Barcelona
NCT01481909Phase 2/Phase 3 (Phase 3)Sep 1, 2010Humboldt University
NCT00258141Phase 4Nov 23, 2005J. Uriach and Company, University of Tampere
NCT00162786Phase 4May 1, 2005J. Uriach and Company, Maastricht University
NCT00199225Phase 1Feb 1, 2005J. Uriach and Company, University of Barcelona
NCT00199251Phase 3Apr 1, 2004J. Uriach and Company
NCT00199238Phase 2Oct 1, 2002J. Uriach and Company
Showing 15 of 15 trials
Page 1 / 1

Organizations

Research & Development (19)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
J. Uriach and CompanyFor profit6642002
Humboldt UniversityAcademic/Hospital3322010
University of BarcelonaAcademic/Hospital3012005
Blueclinical Investigacao E Desenvolvimento Em Saude Lda.Academic/Hospital2012022
Centro Hospitalar de Vila Nova de Gaia/EspinhoAcademic/Hospital2012022
Hospital Pedro HispanoAcademic/Hospital2012022
Noucor Health S.A.For profit2212022
Universidad Autonoma de MadridAcademic/Hospital2012022
Alexandria UniversityAcademic/Hospital1112025
Autonomous University of MadridAcademic/Hospital1012022
Badalona Hospital Germans Trias i PujolAcademic/Hospital1012022
Kafrelsheikh UniversityAcademic/Hospital1012025
Maastricht UniversityAcademic/Hospital1012005
Nanjing Medical UniversityAcademic/Hospital1112024
St. Paul's Sinus CentreAcademic/Hospital1112020
Tanta UniversityAcademic/Hospital1112018
Universidad Autonoma de BarcelonaAcademic/Hospital1012012
Universidad Complutense de MadridAcademic/Hospital1012022
University of TampereAcademic/Hospital1012005
19 organizations
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