dendritic cells
Cell therapyexperimental
A dendritic cell (DC) is an antigen-presenting cell of the mammalian immune system. A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and adaptive immune systems. — Wikipedia
Clinical trial activity
52 trials · 65 clinical orgs · 0 marketing orgs
Phase 1
31
Phase 2
36
Phase 3
1
Phase 4
0
Earliest trial started Jan 1, 2004 (NCT00185874)
Timeline
Indications
Studied for
- Astrocytoma · Phase 1
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 2
- Carcinoma, Hepatocellular · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Carcinoma, Pancreatic Ductal · Phase 1/Phase 2
- Carcinoma, Renal Cell · Phase 2
- Catheters · Phase 1/Phase 2
- Cells · Phase 1/Phase 2
- Colorectal Neoplasms · Phase 2
- Diabetes Mellitus, Type 1 · Phase 1
- Drug Therapy · Phase 1/Phase 2
- Endometrial Neoplasms · Phase 2
- Ependymoma · Phase 1
- Glioblastoma · Phase 2
- Glioma · Phase 1/Phase 2
- Hamartoma · Phase 1/Phase 2
- Head and Neck Neoplasms · Phase 1
- Hepatectomy · Phase 2
- HIV Infections · Phase 1/Phase 2
- Immune Checkpoint Inhibitors · Phase 1/Phase 2
- Immunotherapy · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1/Phase 2
- Liver Neoplasms · Phase 2
- Lung Neoplasms · Phase 1/Phase 2
- Lymphoma · Phase 1/Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 1/Phase 2
- Lymphoma, Follicular · Phase 1/Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 1/Phase 2
- Lymphoma, Large-Cell, Immunoblastic · Phase 1/Phase 2
- Lymphoma, Mantle-Cell · Phase 1/Phase 2
- Lymphoma, Non-Hodgkin · Phase 1/Phase 2
- Medulloblastoma · Phase 1
- Melanoma · Phase 3
- Mesothelioma · Phase 1/Phase 2
- Multiple Myeloma · Phase 2
- Nasopharyngeal Carcinoma · Phase 2
- Neoplasms · Phase 2
- Osteosarcoma · Phase 1
- Ovarian Neoplasms · Phase 2
- Pancreatic Neoplasms · Phase 1/Phase 2
- Peritoneal Neoplasms · Phase 1/Phase 2
- Prostatic Neoplasms · Phase 1
- Radiofrequency Ablation · Phase 2
- Sarcoma · Phase 2
- Stomach Neoplasms · Phase 1/Phase 2
- Urinary Bladder Neoplasms · Phase 1/Phase 2
Mechanism of action
- Unspecified targetImmunity, active
immunity, active
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDendritic cell ↗
Also known as
- dendritic cell
- dendritic cells
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06172634 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2024 | Soonchunhyang University |
| NCT04212377 | Phase 2 | Apr 8, 2019 | Katholieke Universiteit Leuven, Radboud University |
| NCT03067493 | Phase 2 | Apr 1, 2017 | Guangzhou Medical University, Sun Yat-Sen University |
| NCT03035331 | Phase 1/Phase 2 (Phase 2) | Mar 27, 2017 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT02993315 | Phase 3 | Oct 1, 2016 | Radboud University, ZonMw: The Netherlands Organisation for Health Research and Development, Zorginstituut Nederland |
| NCT02873416 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2016 | Ningbo Cancer Hospital, Ningbo No. 5 Hospital, Shanghai Cell Therapy Research Institute |
| NCT02873442 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2016 | Ningbo Cancer Hospital, Ningbo No. 5 Hospital, Shanghai Cell Therapy Research Institute |
| NCT02862613 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2016 | Fudan University |
| NCT02873520 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2016 | Ningbo Cancer Hospital, Ningbo No. 5 Hospital, Shanghai Cell Therapy Research Institute |
| NCT02862561 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2016 | Fudan University |
| NCT02862587 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2016 | Fudan University |
| NCT02886897 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2016 | Sun Yat-Sen University |
| NCT02771301 | N/A | Feb 1, 2016 | Capital Medical University, Hebei University |
| NCT02669719 | Phase 2 | Jan 1, 2016 | Accord Research, Jiao Tong University |
| NCT02638857 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2015 | Eastern Hepatobiliary Surgery Hospital, People's Liberation Army of China |
| NCT02366728 | Phase 2 | Sep 1, 2015 | Duke University |
| NCT02432378 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2015 | Hemispherx Biopharma, National Cancer Institute (NCI), University of Pittsburgh |
| NCT02961829 | N/A | Jul 1, 2015 | Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de São Paulo, University of Sao Paulo, ViiV Healthcare |
| NCT02529579 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2015 | Changhai Hospital, ImmunoGenes, People's Liberation Army of China |
| NCT02423928 | Phase 1 | May 1, 2015 | Alden Cancer Therapy II, Bergen Health, University of Bergen, University of Oslo |
Showing 20 of 52 trials
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Organizations
Research & Development (65)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 8 | 0 | 2 | 2006 |
| University of Pittsburgh | Academic/Hospital | 5 | 5 | 2 | 2006 |
| Radboud University | Academic/Hospital | 4 | 4 | 2 | 2004 |
| Fudan University | Academic/Hospital | 3 | 3 | 1 | 2016 |
| Guangxi Medical University | Academic/Hospital | 3 | 3 | 1 | 2013 |
| Ningbo Cancer Hospital | Academic/Hospital | 3 | 3 | 1 | 2016 |
| Ningbo No. 5 Hospital | Academic/Hospital | 3 | 0 | 1 | 2016 |
| Shanghai Cell Therapy Research Institute | Academic/Hospital | 3 | 0 | 1 | 2016 |
| Dartmouth University | Academic/Hospital | 2 | 2 | 1 | 2006 |
| People's Liberation Army of China | Government | 2 | 1 | 1 | 2015 |
| Stanford University | Academic/Hospital | 2 | 2 | 1 | 2004 |
| Sun Yat-Sen University | Academic/Hospital | 2 | 2 | 1 | 2016 |
| University of California, Los Angeles | Academic/Hospital | 2 | 2 | 2 | 2012 |
| Accord Research | For profit | 1 | 0 | 1 | 2016 |
| Alden Cancer Therapy II | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Bergen Health | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Cancer Research Institute | Academic/Hospital | 1 | 0 | 1 | 2005 |
| Cancer Treatment Research Foundation | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Capital Medical University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Changhai Hospital | Academic/Hospital | 1 | 1 | 1 | 2015 |
65 organizations
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