triflusal
Small moleculeexperimental
Triflusal is a platelet aggregation inhibitor that was discovered and developed in the Uriach Laboratories, and commercialised in Spain since 1981. Currently, it is available in 25 countries in Europe, Asia, Africa and America. It is a derivative of acetylsalicylic acid in which a hydrogen atom on the benzene ring has been replaced by a trifluoromethyl group. Trade names include Disgren, Grendis, Aflen and Triflux. — Wikipedia
Clinical trial activity
6 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
0
Phase 4
3
Earliest trial started Jul 1, 2002 (NCT00162799)
Timeline
2000s
- Jan 1, 2002
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- CyclooxygenaseINHIBITOR
Cyclooxygenase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(=O)Oc1cc(C(F)(F)F)ccc1C(=O)O- Mol. weight
- 248.16 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTriflusal ↗
- ChEMBLCHEMBL1332032 ↗
Also known as
- 2-acetoxy-4-trifluoromethylbenzoic acid
- 2- (acetyloxy)-4-(trifluoromethyl)benzoic acid
- disgren
- disgren
- triflusal
- triflusal
- triflusal
- triflusal
- triflusal
- triflusal
- triflusal
- triflusal
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02904109 | Phase 2 | Sep 13, 2016 | University of Basel |
| NCT02616497 | Phase 4 | Sep 1, 2015 | University of Ioannina |
| NCT02321852 | Phase 2 | Jan 1, 2015 | University of Basel |
| NCT01612273 | Phase 4 | Apr 1, 2011 | Yonsei University |
| NCT01174693 | Phase 4 | Mar 1, 2010 | Myung In Pharmaceutical Company, Yonsei University |
| NCT00162799 | Phase 2 | Jul 1, 2002 | J. Uriach and Company |
Showing 6 of 6 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Basel | Academic/Hospital | 2 | 2 | 1 | 2015 |
| Yonsei University | Academic/Hospital | 2 | 2 | 1 | 2010 |
| J. Uriach and Company | For profit | 1 | 1 | 1 | 2002 |
| Myung In Pharmaceutical Company | For profit | 1 | 0 | 1 | 2010 |
| University of Ioannina | Academic/Hospital | 1 | 1 | 1 | 2015 |
5 organizations
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