tofogliflozin hydrate
Small moleculeexperimental
Clinical trial activity
11 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
3
Phase 3
0
Phase 4
3
Earliest trial started May 1, 2008 (NCT00682097)
Timeline
Indications
Approved for
Mechanism of action
- Sodium/glucose cotransporter 2INHIBITOR
SLC5A2 inhibitor
SGLT2 selective. IC50 rSGLT2= 14.5nM; mSGLT2= 5.0 nM vs IC50 rSGLT1=8200 nM; IC50 mSGLT1, 1800 nM.
Chemistry & pharmacology
Loading structure…
SMILES
CCc1ccc(Cc2ccc3c(c2)[C@]2(OC3)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1- Mol. weight
- 386.44 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2110731 ↗
- ChEMBLCHEMBL2105711 ↗
Also known as
- 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3h),2'-(2h)pyran)-3',4',5'-triol
- apleway
- apleway
- csg452
- csg452
- csg452
- csg452
- deberza
- deberza
- ro4998452
- tofogliflozin
- tofogliflozin
- tofogliflozin
- tofogliflozin
- tofogliflozin
- tofogliflozin
- tofogliflozin
- tofogliflozin
- tofogliflozin anhydrous
- tofogliflozin anhydrous
- tofogliflozin hydrate
- tofogliflozin hydrate
- tofogliflozin hydrate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05722262 | Phase 1 | Feb 24, 2023 | Kowa |
| NCT05327127 | Phase 2 | Nov 14, 2022 | Kowa |
| NCT05469659 | Phase 2 | Sep 22, 2021 | Kowa, Shinshu University |
| NCT04237597 | Phase 1 | Dec 17, 2019 | Kowa |
| NCT02649465 | Phase 4 | Jan 1, 2016 | Kanazawa University, Kowa |
| NCT02537834 | Phase 4 | Aug 1, 2015 | Kowa, Sanofi |
| NCT02201004 | Phase 4 | Jun 1, 2014 | Kowa, Sanofi |
| NCT01044017 | Phase 1 | Dec 1, 2009 | Roche |
| NCT00933972 | Phase 1 | Jun 1, 2009 | Roche |
| NCT00800176 | Phase 2 | Jan 1, 2009 | Roche |
| NCT00682097 | Phase 1 | May 1, 2008 | Roche |
Showing 11 of 11 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Kowa | For profit | 7 | 4 | 3 | 2014 |
| Roche | For profit | 4 | 4 | 2 | 2008 |
| Sanofi | For profit | 2 | 1 | 1 | 2014 |
| Kanazawa University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Shinshu University | Academic/Hospital | 1 | 1 | 1 | 2021 |
5 organizations
Page 1 / 1