autologous dendritic cells
Cell therapyexperimental
Clinical trial activity
79 trials · 73 clinical orgs · 0 marketing orgs
Phase 1
40
Phase 2
46
Phase 3
5
Phase 4
1
Earliest trial started Dec 1, 1996 (NCT00001566)
Timeline
Indications
Approved for
Studied for
- Arthritis, Rheumatoid · Phase 1
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 2
- Carcinoma, Hepatocellular · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Carcinoma, Ovarian Epithelial · Phase 2
- Carcinoma, Renal Cell · Phase 3
- Cholangiocarcinoma · Early Phase 1
- Colorectal Neoplasms · Phase 2
- Crohn Disease · Phase 1
- Diffuse Intrinsic Pontine Glioma · Phase 1
- Drugs, Investigational · Phase 1
- Esophageal Neoplasms · Phase 2
- Fallopian Tube Neoplasms · Phase 3
- Glioblastoma · Phase 3
- Glioma · Phase 1/Phase 2
- Hamartoma · Phase 3
- HIV Infections · Phase 4
- Influenza, Human · Phase 1/Phase 2
- Kidney Neoplasms · Phase 2
- Leukemia · Phase 1
- Liver Cirrhosis, Alcoholic · Phase 3
- Lung Neoplasms · Phase 2
- Lymphoma · Phase 1/Phase 2
- Lymphoma, Follicular · Phase 2
- Medulloblastoma · Phase 1/Phase 2
- Melanoma · Phase 2
- Mesothelioma · Phase 2/Phase 3
- Mesothelioma, Malignant · Phase 1
- Multiple Sclerosis · Phase 1
- Nasopharyngeal Neoplasms · Phase 1/Phase 2
- Neoplasm Metastasis · Phase 1
- Neoplasms · Phase 2
- Neuroectodermal Tumors, Primitive · Phase 1/Phase 2
- Ovarian Neoplasms · Phase 3
- Pancreatic Neoplasms · Phase 1
- Prostatic Neoplasms · Phase 1/Phase 2
- Rhabdomyosarcoma · Phase 2
- Sarcoma · Phase 2
- Sarcoma, Ewing · Phase 2
Mechanism of action
- Unspecified targetImmunity, passive
immunity, passive
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- activated dendritic cells
- ags-003
- ags-003-bld
- autologous dendritic cell
- autologous dendritic cells
- autologous dendritic cells.
- autologous dendritic cells generated using gm-csf, interferon alpha and lps
- autologous mature dendritic cells
- autologous tolerogenic dendritic cells
- polarized dendritic cells
- renal cell carcinoma/cd40l rna-transfected autologous dendritic cell vaccine ags-003
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06342908 | Phase 1 | Dec 8, 2024 | University of California, Los Angeles |
| NCT06193733 | Phase 2 | Feb 19, 2024 | Chang Gung University |
| NCT06015269 | Phase 1 | Aug 31, 2023 | Shanghai Cell Therapy Group Co.,Ltd, Shanghai University |
| NCT05518032 | Phase 2 | Feb 1, 2023 | State University of New York, Buffalo |
| NCT07202611 | Phase 2 | Dec 2, 2022 | National Taiwan University |
| NCT05261750 | Phase 1/Phase 2 (Phase 2) | Apr 30, 2022 | Prodia StemCell Indonesia |
| NCT05304208 | Phase 1 | Nov 2, 2021 | Erasmus University Rotterdam |
| NCT05650918 | Phase 1 | Aug 30, 2021 | Erasmus University Rotterdam |
| NCT05093881 | N/A | Aug 24, 2021 | Pharmicell Co., Ltd., Wonju Christian Hospital |
| NCT04834544 | Phase 2 | Apr 19, 2021 | Peking University, SOTIO a.s. |
| NCT04689152 | Phase 3 | Mar 2, 2021 | Pharmicell Co., Ltd., Wonju Christian Hospital |
| NCT04614051 | Phase 1 | Dec 31, 2020 | Pharmicell Co., Ltd., University of Ulsan |
| NCT04277221 | Phase 3 | Oct 18, 2019 | Chang Gung University, Safe Save Medical Cell Sciences & Technology Co.,Ltd. |
| NCT03905902 | Phase 3 | Sep 30, 2019 | Accord Research |
| NCT04115761 | Phase 2 | Jun 6, 2019 | Ever Supreme Bio Technology Co., Ltd. |
| NCT03942328 | Early Phase 1 (Phase 1) | May 17, 2019 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT03815084 | Early Phase 1 (Phase 1) | Feb 1, 2019 | Allife Medical Science and Technology Co., Ltd., Henan Medical University, Peking University, The First People's Hospital of Yunan Province |
| NCT03758625 | Phase 1 | Nov 30, 2018 | National Institute of Allergy and Infectious Diseases (NIAID), University of Pittsburgh |
| NCT03546426 | Phase 1 | Aug 31, 2018 | Istituto Nazionale per lo Studio e la Cura dei Tumori |
| NCT03610360 | Phase 2/Phase 3 (Phase 3) | Jun 21, 2018 | Amphera BV, TMC Pharma |
Showing 20 of 79 trials
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Organizations
Research & Development (73)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 25 | 2 | 3 | 1996 |
| Argos Therapeutics | For profit | 4 | 4 | 2 | 2006 |
| Duke University | Academic/Hospital | 4 | 4 | 3 | 2000 |
| Hoag Memorial Hospital Presbyterian | Academic/Hospital | 4 | 2 | 1 | 2000 |
| University of California, Los Angeles | Academic/Hospital | 4 | 4 | 1 | 2000 |
| Chang Gung University | Academic/Hospital | 3 | 1 | 3 | 2016 |
| Mayo Clinic | Academic/Hospital | 3 | 3 | 3 | 2016 |
| Pharmicell Co., Ltd. | For profit | 3 | 3 | 3 | 2020 |
| University of Barcelona | Academic/Hospital | 3 | 2 | 2 | 2006 |
| University of Pittsburgh | Academic/Hospital | 3 | 3 | 2 | 2002 |
| Accord Research | For profit | 2 | 2 | 2 | 2017 |
| Baylor University | Academic/Hospital | 2 | 2 | 2 | 2001 |
| Caladrius Biosciences | For profit | 2 | 2 | 1 | 2000 |
| Cedars-Sinai Medical Center | Academic/Hospital | 2 | 1 | 2 | 2007 |
| Clinica Universidad de Navarra | Academic/Hospital | 2 | 2 | 1 | 2009 |
| Erasmus University Rotterdam | Academic/Hospital | 2 | 2 | 1 | 2021 |
| Harvard University | Academic/Hospital | 2 | 2 | 1 | 2004 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 2 | 0 | 2 | 2009 |
| National Institutes of Health (NIH) | Government | 2 | 0 | 1 | 1996 |
| Peking University | Academic/Hospital | 2 | 1 | 2 | 2019 |
73 organizations
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