CDEK
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cenicriviroc

Small moleculeexperimental

Cenicriviroc is an experimental drug candidate for the treatment of HIV infection and in combination with Tropifexor for non-alcoholic steatohepatitis. It is being developed by Takeda and Tobira Therapeutics. — Wikipedia

Clinical trial activity

19 trials · 30 clinical orgs · 0 marketing orgs

Phase 1
6
Phase 2
14
Phase 3
2
Phase 4
0

Earliest trial started Feb 1, 2009 (NCT01092104)

Timeline

2000s

  1. Jan 1, 2009

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2011

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2017

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CC(C)C)cc1
Mol. weight
696.96 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • cenicriviroc
  • cenicriviroc
  • cenicriviroc
  • cenicriviroc
  • cenicriviroc
  • cenicriviroc mesylate
  • cenicriviroc mesylate
  • tak 652
  • tak-652
  • tak-652
  • tak-652
  • tbr652
  • tbr 652
  • tbr-652
  • tbr-652
  • tbr-652
  • tbr-652

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05630885Phase 2Feb 20, 2023AbbVie, Harvard University, National Institute of Allergy and Infectious Diseases (NIAID)
NCT04334915Phase 2Dec 1, 2020Allergan, Harvard University, National Institute of Allergy and Infectious Diseases (NIAID)
NCT04593940Phase 3Oct 15, 2020Department of Health and Human Services, Duke University, National Center for Advancing Translational Science (NCATS), Washington University in St. Louis
NCT04500418Phase 2Aug 25, 2020Allergan, Charité University, Berlin, Germany, Humboldt University
NCT04488081Phase 2Jul 31, 2020Columbia University, Emory University, QuantumLeap Healthcare Collaborative, Sanford Health, University of Alabama, Birmingham, University of California, San Diego, University of California, San Francisco, University of Colorado, Denver, University of Minnesota, University of Pennsylvania, University of Southern California, Wake Forest University, Yale University, Yeshiva University
NCT03517540Phase 2Aug 10, 2018Allergan, Novartis
NCT03376841Phase 1Jun 6, 2017Allergan
NCT03028740Phase 3Apr 4, 2017Allergan, Tobira Therapeutics, Inc.
NCT03059446Phase 2Feb 14, 2017Tobira Therapeutics, Inc.
NCT02653625Phase 2Mar 14, 2016Tobira Therapeutics, Inc.
NCT02684799Phase 1Jan 1, 2016Tobira Therapeutics, Inc.
NCT02330549Phase 2Jun 1, 2015Tobira Therapeutics, Inc.
NCT02342067Phase 1Dec 1, 2014Tobira Therapeutics, Inc.
NCT02217475Phase 2Sep 1, 2014Tobira Therapeutics, Inc.
NCT02128828Phase 2Apr 1, 2014Tobira Therapeutics, Inc., University of Hawaii
NCT02120547Phase 1Mar 1, 2014Clinical Pharmacology of Miami, Tobira Therapeutics, Inc.
NCT01827540Phase 1Mar 1, 2013SeaView Research, Tobira Therapeutics, Inc., ViiV Healthcare
NCT01338883Phase 2Jun 1, 2011Tobira Therapeutics, Inc.
NCT01092104Phase 1/Phase 2 (Phase 2)Feb 1, 2009Tobira Therapeutics, Inc.
Showing 19 of 19 trials
Page 1 / 1

Organizations

Research & Development (30)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Tobira Therapeutics, Inc.For profit121132009
AllerganFor profit5132017
Harvard UniversityAcademic/Hospital2012020
National Institute of Allergy and Infectious Diseases (NIAID)Government2212020
AbbVieFor profit1012023
Charité University, Berlin, GermanyAcademic/Hospital1012020
Clinical Pharmacology of MiamiFor profit1012014
Columbia UniversityAcademic/Hospital1012020
Department of Health and Human ServicesGovernment1012020
Duke UniversityAcademic/Hospital1112020
Emory UniversityAcademic/Hospital1012020
Humboldt UniversityAcademic/Hospital1112020
National Center for Advancing Translational Science (NCATS)Government1012020
NovartisFor profit1112018
QuantumLeap Healthcare CollaborativeAcademic/Hospital1112020
Sanford HealthAcademic/Hospital1012020
SeaView ResearchFor profit1012013
University of Alabama, BirminghamAcademic/Hospital1012020
University of California, San DiegoAcademic/Hospital1012020
University of California, San FranciscoAcademic/Hospital1012020
30 organizations
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