Ursodoxicoltaurine

Small moleculeexperimental

Ursodoxicoltaurine is the international nonproprietary name (INN) for the pharmaceutical form of tauroursodeoxycholic acid (TUDCA). It is also known as taurursodiol. Tauroursodeoxycholic acid is a naturally occurring hydrophilic bile acid which is the taurine conjugated form of ursodeoxycholic acid (UDCA). Humans have only trace amounts of tauroursodeoxycholic acid but bears have large amounts of tauroursodeoxycholic acid and ursodeoxycholic acid in their bile. — Wikipedia

Clinical trial activity

12 trials · 32 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Sep 1, 1997 (NCT00004441)

Timeline

2000s

Jan 1, 2008
Earliest Phase 2 Sponsor(trial)
Jan 1, 2009
Earliest Phase 3 Sponsor(trial)

2010s

Jan 1, 2013
Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Amyotrophic Lateral Sclerosis

Studied for

Mechanism of action

Histone deacetylaseINHIBITOR
Histone deacetylase inhibitor

Chemistry & pharmacology

Oral

Parenteral

Topical

Sources

WikipediaUrsodoxicoltaurine ↗
WikipediaTauroursodeoxycholic acid ↗

Also known as

tauroursodeoxycholate
tauroursodeoxycholate
tauroursodeoxycholate
tauroursodeoxycholic acid
tauroursodeoxycholic acid
tauroursodeoxycholic acid
tauroursodeoxycholic acid
tauroursodeoxycholic acid, (3alpha,5alpha,7alpha)-isomer
tauroursodeoxycholic acid, monosodium salt, (3alpha,5beta,7alpha)-isomer
tauroursodeoxycholic acid, monosodium salt, (3alpha,7alpha)-isomer
tauroursodesoxycholic acid
tauroursodesoxycholic acid
tudca
tudca
tudca
ursodeoxycholyltaurine
ursodeoxycholyltaurine

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT03127514	Phase 2	Jun 1, 2017	ALS Association, ALS Finding a Cure Foundation, Amylyx Pharmaceuticals Inc., Harvard University, Leandro P. Rizzuto Foundation, Northeast ALS Consortium
NCT02218619	Phase 2	Aug 1, 2015	Columbia University, Juvenile Diabetes Research Foundation
NCT01877551	N/A	Sep 1, 2013	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Washington University in St. Louis
NCT01855360	Phase 1/Phase 2 (Phase 2)	Jun 1, 2013	Harvard University
NCT01998451	Phase 4	Dec 1, 2012	Guangzhou Medical University, Guizhou Medical University
NCT01171859	Phase 2	Jul 1, 2010	University of Pavia
NCT01857284	Phase 3	Sep 1, 2009	Beijing Trendful Kangjian Medical Information Consulting Limited Company, Capital Medical University
NCT01829698	Phase 3	Aug 1, 2009	Beijing Trendful Kangjian Medical Information Consulting Limited Company, Capital Medical University, Fudan University, Huazhong University of Science and Technology, Jiao Tong University, Kunming Medical University, NO.6 People's Hospital of Hangzhou, Peking University, People's Liberation Army of China, Second Military Medical University, Sichuan University, Southern Medical University, Sun Yat-Sen University, Zhejiang University
NCT00877604	Phase 2	Jun 1, 2008	Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, University of Naples Frederico II, University of Palermo
NCT00771901	N/A	Feb 1, 2008	Washington University in St. Louis
NCT00004410	N/A	Jun 1, 1998	University of Cincinnati
NCT00004441	N/A	Sep 1, 1997	University of Cincinnati

Showing 12 of 12 trials

Page 1 / 1

Organizations

Research & Development (32)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Beijing Trendful Kangjian Medical Information Consulting Limited Company	For profit	2	1	1	2009
Capital Medical University	Academic/Hospital	2	1	1	2009
Harvard University	Academic/Hospital	2	1	1	2013
University of Cincinnati	Academic/Hospital	2	2	1	1997
Washington University in St. Louis	Academic/Hospital	2	2	1	2008
ALS Association	Academic/Hospital	1	0	1	2017
ALS Finding a Cure Foundation	Academic/Hospital	1	0	1	2017
Amylyx Pharmaceuticals Inc.	For profit	1	1	1	2017
Columbia University	Academic/Hospital	1	1	1	2015
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta	Academic/Hospital	1	1	1	2008
Fudan University	Academic/Hospital	1	0	1	2009
Guangzhou Medical University	Academic/Hospital	1	1	1	2012
Guizhou Medical University	Academic/Hospital	1	0	1	2012
Huazhong University of Science and Technology	Academic/Hospital	1	0	1	2009
Jiao Tong University	Academic/Hospital	1	0	1	2009
Juvenile Diabetes Research Foundation	Academic/Hospital	1	0	1	2015
Kunming Medical University	Academic/Hospital	1	0	1	2009
Leandro P. Rizzuto Foundation	Academic/Hospital	1	0	1	2017
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Government	1	0	1	2013
National Institutes of Health (NIH)	Government	1	0	1	2013

32 organizations

Page 1 / 2