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sodium stibogluconate

Trade name: Pentostam

Small moleculeexperimental

Sodium stibogluconate, sold under the brand name Pentostam among others, is a medication used to treat leishmaniasis. This includes leishmaniasis of the cutaneous, visceral, and mucosal types. Some combination of miltefosine, paromomycin and liposomal amphotericin B, however, may be recommended due to issues with resistance. It is given by injection. — Wikipedia

Clinical trial activity

20 trials · 33 clinical orgs · 0 marketing orgs

Phase 1
5
Phase 2
13
Phase 3
3
Phase 4
1

Earliest trial started Jun 1, 2002 (NCT00662012)

Timeline

2000s

  1. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2004

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Mol. weight
907.88 g/mol
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • estibogluconato sodico
  • myostibin
  • myostibin
  • myostibin
  • natrii stibogluconas
  • pentostam
  • pentostam
  • pentostam
  • pentostam
  • pentostam
  • sodium stibogluconate
  • sodium stibogluconate
  • sodium stibogluconate
  • sodium stibogluconate
  • sodium stibogluconate
  • sodium stibogluconate
  • sodium stibogluconate
  • sodium stibogluconate
  • solusurmin
  • stibanate
  • stibanose
  • stibatin
  • stibatin
  • stibatin
  • stibinol
  • stibogluconate de sodium
  • stibogluconate sodium
  • trisodium 1-{[3-carboxylato-5-(1,2-dihydroxyethyl)-1-hydroxy-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]hept-1-yl]oxy}-5-(1,2-dihydroxyethyl)-1-oxido-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]heptane-3-carboxylate nonahydrate
  • trisodium 1-{[3-carboxylato-5-(1,2-dihydroxyethyl)-1-hydroxy-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]hept-1-yl]oxy}-5-(1,2-dihydroxyethyl)-1-oxido-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]heptane-3-carboxylate nonahydrate

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06798402Phase 2Feb 7, 2025Al-Mustafa University College, Al-Mustansiriyah University
NCT05957978Phase 2Jan 31, 2024Drugs for Neglected Diseases Initiative, Novartis, University of Gondar
NCT05708625Phase 3Jan 1, 2022Zagazig University
NCT04906031Phase 2Jun 1, 2020Jiao Tong University, Jinan University
NCT03129646Phase 3Aug 1, 2017Drugs for Neglected Diseases Initiative, Institute of Endemic Diseases, Sudan, Kenya Medical Research Institute, Makerere University, Netherlands Cancer Institute, University of Gondar, University of Khartoum
NCT03009422N/ANov 1, 2014Tel Aviv University
NCT01067443Phase 2Mar 1, 2010Drugs for Neglected Diseases Initiative, Gilead Sciences, Kenya Medical Research Institute, Paladin Labs
NCT00996463Phase 2Jan 1, 2010German Federal Ministry of Education and Research, University of Heidelberg, Waisenmedizin e. V. Promoting Access to Essential Medicine
NCT01011309Phase 2Oct 1, 2009Immune Design, Infectious Disease Research Institute
NCT01661296Phase 4Aug 1, 2009Ohio State University, Sarder Patel Medical College, SP Medical College, Bikaner
NCT01009502Phase 1Jul 1, 2009Northwestern University
NCT00508963N/AJul 27, 2007University of California, San Francisco
NCT00498979Phase 1May 1, 2007Case Western Reserve University, National Cancer Institute (NCI), University of Rochester
NCT00629200Phase 1Sep 1, 2006University of Texas at Houston, VioQuest Pharmaceuticals
NCT01479309Phase 2Sep 1, 2006University of Texas at Houston, VioQuest Pharmaceuticals
NCT00311558Phase 1Oct 1, 2005National Cancer Institute (NCI), University of Rochester
NCT00255567Phase 3Nov 1, 2004Drugs for Neglected Diseases Initiative
NCT00657618Phase 1/Phase 2 (Phase 2)Oct 1, 2004United States Army
NCT00884377Phase 2Feb 1, 2004Uniformed Services University of the Health Sciences, United States Army
NCT00662012Phase 2Jun 1, 2002United States Army
Showing 20 of 20 trials
Page 1 / 1

Organizations

Research & Development (33)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Drugs for Neglected Diseases InitiativeAcademic/Hospital4422004
United States ArmyGovernment3312002
Kenya Medical Research InstituteAcademic/Hospital2022010
National Cancer Institute (NCI)Government2012005
University of GondarAcademic/Hospital2022017
University of RochesterAcademic/Hospital2112005
University of Texas at HoustonAcademic/Hospital2222006
VioQuest PharmaceuticalsFor profit2022006
Al-Mustafa University CollegeAcademic/Hospital1112025
Al-Mustansiriyah UniversityAcademic/Hospital1012025
Case Western Reserve UniversityAcademic/Hospital1112007
German Federal Ministry of Education and ResearchGovernment1012010
Gilead SciencesFor profit1012010
Immune DesignFor profit1012009
Infectious Disease Research InstituteAcademic/Hospital1112009
Institute of Endemic Diseases, SudanAcademic/Hospital1012017
Jiao Tong UniversityAcademic/Hospital1012020
Jinan UniversityAcademic/Hospital1112020
Makerere UniversityAcademic/Hospital1012017
Netherlands Cancer InstituteAcademic/Hospital1012017
33 organizations
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