sodium butyrate
Sodium butyrate is a compound with formula Na(C3H7COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression. As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes. — Wikipedia
Clinical trial activity
23 trials · 32 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2005 (NCT00800930)
Timeline
Indications
Studied for
- Arthritis, Rheumatoid · Phase 2
- Butyrates · Phase 2
- Cognition · Phase 2/Phase 3
- Cognitive Dysfunction · Phase 2/Phase 3
- Colitis, Ulcerative · Phase 2
- Diabetes Mellitus, Type 1 · Phase 1/Phase 2
- Dysentery, Bacillary · Phase 2
- Fatty Liver · Phase 3
- Graft vs Host Disease · Phase 2
- Hypertension · Phase 1
- Schizophrenia · Phase 2/Phase 3
Mechanism of action
- NF-kappaB inhibitor alphaINHIBITOR
NFKBIA inhibitor
Chemistry & pharmacology
SMILES
CCCC(=O)[O-].[Na+]- Mol. weight
- 110.09 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSodium butyrate ↗
- ChEMBLCHEMBL62381 ↗
Also known as
- sodium butyrate
- sodium butyrate
- sodium butyrate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06514573 | N/A | Sep 2, 2024 | Istituto Superiore di Sanità, University of Naples Frederico II, University of Rome Tor Vergata |
| NCT06700785 | N/A | May 3, 2024 | The Center for Applied Health Sciences, LLC |
| NCT06759363 | Phase 3 | Jan 4, 2024 | University Medical Center Zvezdara, University of Belgrade |
| NCT05808985 | Phase 2 | Sep 2, 2022 | Soonchunhyang University |
| NCT05576597 | Phase 2 | Aug 23, 2022 | Peking University |
| NCT05420805 | N/A | Apr 1, 2022 | Azienda Ospedaliera Universitaria Senese, University of Milan |
| NCT05013060 | N/A | Apr 15, 2021 | Medical University of Lodz, Nordic Bioscience |
| NCT06022588 | N/A | Mar 1, 2021 | Erasmus University Rotterdam |
| NCT04673656 | N/A | Jan 15, 2021 | BioKier Inc. |
| NCT04415333 | Phase 1 | Sep 30, 2020 | North Carolina Agriculture & Technical State University, North Carolina A&T State Univeristy, University of North Carolina at Chapel Hill |
| NCT04259060 | Phase 2 | Jun 30, 2020 | Harvard University |
| NCT04279444 | N/A | Mar 13, 2020 | BioKier Inc. |
| NCT03999853 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2019 | BioKier Inc., Mayo Clinic |
| NCT04073927 | N/A | Aug 5, 2019 | Folkhalsan Research Center, Steno Diabetes Center Copenhagen |
| NCT05249023 | N/A | Apr 11, 2018 | Orebro University |
| NCT03274648 | N/A | Oct 31, 2017 | University of Florence |
| NCT03010865 | Phase 2/Phase 3 (Phase 3) | Jun 1, 2017 | Jiao Tong University, Stanley Medical Research Institute |
| NCT02654405 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2016 | New York University, Stanley Medical Research Institute |
| NCT05456763 | N/A | Jun 30, 2013 | Centre of Postgraduate Medical Education |
| NCT02271802 | N/A | Jun 1, 2009 | Maastricht University, Top Institute Food and Nutrition |