sjg-136
Small moleculeexperimental
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2004 (NCT00103220)
Timeline
Indications
Studied for
- Fallopian Tube Neoplasms · Phase 2
- Hamartoma · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1
- Leukemia, Myeloid, Acute · Phase 1
- Leukemia, Myeloid, Chronic-Phase · Phase 1
- Myelodysplastic Syndromes · Phase 1
- Neoplasms · Phase 1
- Ovarian Neoplasms · Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
Mechanism of action
- DNACROSS-LINKING AGENT
DNA cross-linking agent
Chemistry & pharmacology
Loading structure…
SMILES
C=C1C[C@H]2C=Nc3cc(OCCCOc4cc5c(cc4OC)C(=O)N4CC(=C)C[C@H]4C=N5)c(OC)cc3C(=O)N2C1- Mol. weight
- 556.62 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL16498 ↗
Also known as
- 1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)
- nsc694501
- nsc 694501
- nsc-694501
- sjg136
- sjg 136
- sjg-136
- sjg-136
- sjg-136
- sjg-136
- uglydimer1 cpd
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01200797 | Phase 2 | Jul 1, 2010 | National Cancer Institute (NCI), University of South Florida |
| NCT00301769 | Phase 1 | Dec 1, 2005 | National Cancer Institute (NCI), University of Texas at Houston |
| NCT00121290 | Phase 1 | Feb 1, 2005 | National Cancer Institute (NCI), Vanderbilt University |
| NCT00103220 | Phase 1 | Nov 1, 2004 | Cornell University, National Cancer Institute (NCI) |
Showing 4 of 4 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 4 | 4 | 2 | 2004 |
| Cornell University | Academic/Hospital | 1 | 0 | 1 | 2004 |
| University of South Florida | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2005 |
| Vanderbilt University | Academic/Hospital | 1 | 0 | 1 | 2005 |
5 organizations
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