resatorvid
Small moleculeexperimental
Resatorvid (TAK-242) is a cyclohexane derivative that was invented by scientists at Takeda in a drug discovery campaign to identify inhibitors of the receptor TLR4. It binds directly to cysteine residue 747 intracellularly, preventing TLR4 binding with TIRAP and thus preventing downstream signal transduction. — Wikipedia
Clinical trial activity
4 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
4
Phase 3
2
Phase 4
0
Earliest trial started Sep 1, 2005 (NCT00143611)
Timeline
Indications
Mechanism of action
- Toll-like receptor 4INHIBITOR
TLR4 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl- Mol. weight
- 361.82 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaResatorvid ↗
- ChEMBLCHEMBL225157 ↗
Also known as
- cli095
- cli 095
- cli-095
- ethyl 6-(n-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate
- ethyl (6r)-6-(n-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate
- ethyl cfscc
- resatorvid
- resatorvid
- resatorvid
- tak242
- tak 242
- tak-242
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06890039 | Phase 2 | Sep 1, 2025 | Assistance Publique - Hôpitaux de Paris, European Foundation for Study of Chronic Liver Failure, Humboldt University, Leiden University, University of Leipzig, University of London, Yaqrit Ltd |
| NCT04620148 | Phase 2 | Nov 30, 2020 | Akaza Bioscience Ltd, IQVIA |
| NCT00633477 | Phase 3 | Feb 1, 2008 | Takeda |
| NCT00143611 | Phase 3 | Sep 1, 2005 | Takeda |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Takeda | For profit | 2 | 2 | 1 | 2005 |
| Akaza Bioscience Ltd | For profit | 1 | 1 | 1 | 2020 |
| Assistance Publique - Hôpitaux de Paris | Academic/Hospital | 1 | 0 | 1 | 2025 |
| European Foundation for Study of Chronic Liver Failure | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Humboldt University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| IQVIA | For profit | 1 | 0 | 1 | 2020 |
| Leiden University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of Leipzig | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of London | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Yaqrit Ltd | For profit | 1 | 1 | 1 | 2025 |
10 organizations
Page 1 / 1