interleukin-15
Recombinant proteinexperimental
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain. IL-15 is secreted by mononuclear phagocytes following infection by virus(es). This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells. — Wikipedia
Clinical trial activity
16 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
14
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2007 (NCT00528489)
Timeline
Indications
Studied for
- B-Lymphocytes · Phase 1
- Brain Neoplasms · Phase 1
- Bronchiectasis · Phase 1
- Carcinoma · Phase 1
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Carcinoma, Renal Cell · Phase 2
- HIV Infections · Phase 1
- Leukemia · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1
- Leukemia-Lymphoma, Adult T-Cell · Phase 1
- Leukemia, Myeloid, Acute · Phase 2
- Leukemia, Prolymphocytic, T-Cell · Phase 1
- Lymphoma · Phase 1
- Lymphoma, Large-Cell, Anaplastic · Phase 1
- Lymphoma, T-Cell · Phase 1
- Melanoma · Phase 1/Phase 2
- Mycosis Fungoides · Phase 1
- Myelodysplastic Syndromes · Phase 1
- Neoplasms · Phase 1
- Neuroblastoma · Phase 1
- Sarcoma · Phase 1
- Sezary Syndrome · Phase 1
- Skin Neoplasms · Phase 1/Phase 2
- Squamous Cell Carcinoma of Head and Neck · Phase 1
Mechanism of action
- Interleukin-15Supplementation
IL15 supplementation
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaInterleukin 15 ↗
Also known as
- il-15
- interleukin-15
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06995872 | Phase 1 | Oct 21, 2025 | National Cancer Institute (NCI) |
| NCT04185220 | Phase 1 | Dec 9, 2019 | National Cancer Institute (NCI) |
| NCT04150562 | Phase 2 | Dec 6, 2019 | National Cancer Institute (NCI) |
| NCT03759184 | Phase 1 | Jul 5, 2019 | National Cancer Institute (NCI) |
| NCT03905135 | Phase 1 | Jun 7, 2019 | National Cancer Institute (NCI) |
| NCT03388632 | Phase 1 | Feb 5, 2018 | National Cancer Institute (NCI) |
| NCT02689453 | Phase 1 | Jan 28, 2016 | National Cancer Institute (NCI) |
| NCT02395822 | Phase 2 | Oct 1, 2015 | University of Minnesota |
| NCT01875601 | Phase 1 | May 21, 2013 | National Cancer Institute (NCI) |
| NCT01727076 | Phase 1 | Feb 1, 2013 | Cancer Immunotherapy Trials Network, National Cancer Institute (NCI) |
| NCT01572493 | Phase 1 | Apr 2, 2012 | National Cancer Institute (NCI) |
| NCT01385423 | Phase 1 | Sep 1, 2011 | University of Minnesota |
| NCT01369888 | Phase 1/Phase 2 (Phase 2) | May 1, 2011 | National Cancer Institute (NCI), National Institutes of Health (NIH) |
| NCT01021059 | Phase 1 | Nov 10, 2009 | National Cancer Institute (NCI) |
| NCT00775424 | Phase 1 | Sep 1, 2008 | Drexel University, University of Pennsylvania |
| NCT00528489 | Phase 1 | Oct 1, 2007 | HIV Vaccine Trials Network, National Institute of Allergy and Infectious Diseases (NIAID), University of Washington |
Showing 16 of 16 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 12 | 12 | 2 | 2009 |
| University of Minnesota | Academic/Hospital | 2 | 2 | 2 | 2011 |
| Cancer Immunotherapy Trials Network | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Drexel University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| HIV Vaccine Trials Network | Academic/Hospital | 1 | 0 | 1 | 2007 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 2007 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2011 |
| University of Pennsylvania | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Washington | Academic/Hospital | 1 | 0 | 1 | 2007 |
9 organizations
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