ravuconazole
Small moleculeexperimental
Ravuconazole is a potent triazole antifungal, the development of which was discontinued in 2007. The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes. — Wikipedia
Clinical trial activity
1 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2003 (NCT00064311)
Timeline
2000s
- Jan 1, 2003
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Breast Neoplasms · Phase 1/Phase 2
- Gestational Trophoblastic Disease · Phase 1/Phase 2
- Infections · Phase 1/Phase 2
- Leukemia · Phase 1/Phase 2
- Lymphoma · Phase 1/Phase 2
- Multiple Myeloma · Phase 1/Phase 2
- Myelodysplastic Syndromes · Phase 1/Phase 2
- Myeloproliferative Disorders · Phase 1/Phase 2
- Neuroblastoma · Phase 1/Phase 2
- Ovarian Neoplasms · Phase 1/Phase 2
- Testicular Neoplasms · Phase 1/Phase 2
Mechanism of action
- Cytochrome P450 51INHIBITOR
ERG11 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F- Mol. weight
- 437.48 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaRavuconazole ↗
- ChEMBLCHEMBL294029 ↗
Also known as
- 3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1h-1,2,4-triazol-1-yl)-2-butanol
- bms-207147
- bms-207147
- bms-207147
- er 30346
- er-30346
- er-30346
- er-30346
- ravuconazole
- ravuconazole
- ravuconazole
- ravuconazole
- ravuconazole
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00064311 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2003 | National Cancer Institute (NCI), National Institutes of Health (NIH) |
Showing 1 of 1 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2003 |
| National Institutes of Health (NIH) | Government | 1 | 1 | 1 | 2003 |
2 organizations
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