perfluorobutane
Trade name: Sonazoid
Small moleculeexperimental
Perfluorobutane (PFB) is an inert, high-density colorless gas. It is a simple fluorocarbon with a n-butane skeleton and all the hydrogen atoms replaced with fluorine atoms. — Wikipedia
Clinical trial activity
16 trials · 15 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
10
Phase 3
5
Phase 4
1
Earliest trial started Aug 1, 2004 (NCT00156780)
Timeline
Indications
Approved for
Studied for
- Blood Pressure · Phase 2
- Breast Neoplasms · Phase 1/Phase 2
- Carcinoma, Hepatocellular · Phase 3
- Cardiac Catheterization · Phase 2
- Coronary Artery Disease · Phase 3
- Echocardiography · Phase 2
- Fibrosis · Phase 3
- Healthy Volunteers · Phase 1
- Heart Failure · Phase 2
- Heart Ventricles · Phase 2
- Hypertension, Portal · Phase 4
- Kidney Transplantation · Phase 2
- Liver · Phase 3
- Liver Diseases · Phase 4
- Liver Neoplasms · Phase 3
- Neoplasm Metastasis · Phase 3
- Peripheral Arterial Disease · Phase 2
- Pulmonary Disease, Chronic Obstructive · Phase 1
Mechanism of action
- Unspecified targetOTHER
Diagnostic
- UnclearContrast agent
Unclear contrast agent
Chemistry & pharmacology
Loading structure…
SMILES
FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F- Mol. weight
- 238.02 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPerfluorobutane ↗
- ChEMBLCHEMBL2104979 ↗
Also known as
- ai 700
- ai-700
- ai-700
- ai-700
- ai-700
- ai700 compound
- decafluorobutane
- decafluorobutane
- decafluorobutane
- decafluoro-butane
- mp1950
- mp 1950
- mp-1950
- perflubutane
- perflubutane
- perflubutane
- perflubutane
- perflubutane
- perflubutane
- perflubutane
- perflubutane
- perflubutane polymer microspheres
- perfluorobutane
- perfluorobutane
- perfluorobutane sulfonate
- sonazoid
- sonazoid
- sonazoid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05470205 | Phase 3 | Aug 15, 2022 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Thomas Jefferson University, University of Bern, University of Pennsylvania |
| NCT04720456 | Phase 2 | Nov 30, 2021 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Thomas Jefferson University, University of Pennsylvania |
| NCT05068076 | N/A | Oct 4, 2021 | Institute of Liver and Biliary Sciences, India |
| NCT04006275 | Phase 3 | Jun 30, 2019 | Zhejiang University |
| NCT03245255 | Phase 2 | Dec 4, 2017 | General Electric, National Heart, Lung, and Blood Institute (NHLBI), Thomas Jefferson University |
| NCT02651090 | Phase 3 | May 1, 2017 | Northeastern Ohio Radiology Research and Education Fund |
| NCT03009266 | N/A | Feb 1, 2017 | Oregon Health and Science University |
| NCT02737865 | N/A | May 1, 2016 | Sungkyunkwan University |
| NCT02733029 | Phase 2 | May 1, 2016 | General Electric, Harvard University |
| NCT02652923 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2016 | General Electric, National Cancer Institute (NCI), Siemens, Thomas Jefferson University |
| NCT02398266 | Phase 2 | Jan 1, 2016 | Oregon Health and Science University |
| NCT02489045 | Phase 4 | Apr 6, 2015 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Thomas Jefferson University, University of Pennsylvania |
| NCT03340870 | Phase 1 | Oct 20, 2014 | General Electric |
| NCT03335566 | Phase 3 | May 11, 2014 | General Electric |
| NCT00669851 | Phase 3 | Nov 1, 2006 | Acusphere |
| NCT00156780 | Phase 1 | Aug 1, 2004 | Acusphere |
Showing 16 of 16 trials
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Organizations
Research & Development (15)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| General Electric | For profit | 5 | 2 | 3 | 2014 |
| Thomas Jefferson University | Academic/Hospital | 5 | 5 | 3 | 2015 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 3 | 0 | 3 | 2015 |
| University of Pennsylvania | Academic/Hospital | 3 | 0 | 3 | 2015 |
| Acusphere | For profit | 2 | 2 | 2 | 2004 |
| Oregon Health and Science University | Academic/Hospital | 2 | 2 | 2 | 2016 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Institute of Liver and Biliary Sciences, India | Academic/Hospital | 1 | 1 | 1 | 2021 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2016 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2017 |
| Northeastern Ohio Radiology Research and Education Fund | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Siemens | For profit | 1 | 0 | 1 | 2016 |
| Sungkyunkwan University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Bern | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2019 |
15 organizations
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