cmv-specific t-cells
Cell therapyexperimental
Clinical trial activity
29 trials · 34 clinical orgs · 0 marketing orgs
Phase 1
19
Phase 2
14
Phase 3
1
Phase 4
1
Earliest trial started Nov 1, 1997 (NCT00712634)
Timeline
Indications
Approved for
Studied for
- Acne Vulgaris · Phase 2
- Adenoviridae · Phase 1/Phase 2
- Cytomegalovirus · Phase 2
- Cytomegalovirus Infections · Phase 4
- Epstein-Barr Virus Infections · Phase 1/Phase 2
- Glioblastoma · Phase 1/Phase 2
- Graft vs Host Disease · Phase 2
- Hematologic Diseases · Phase 4
- Hematologic Neoplasms · Phase 2
- Hematopoietic Stem Cell Transplantation · Phase 1
- Hodgkin Disease · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 2
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive · Phase 2
- Leukemia, Myeloid, Acute · Phase 2
- Lymphoma · Phase 2
- Lymphoma, Large-Cell, Immunoblastic · Phase 2
- Lymphoma, Non-Hodgkin · Phase 2
- Multiple Myeloma · Phase 1
- Myelodysplastic Syndromes · Phase 2
- Myeloproliferative Disorders · Phase 2
- Neoplasms · Phase 1
- Opportunistic Infections · Phase 1
- Organ Transplantation · Phase 1
- Precancerous Conditions · Phase 1
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 2
- Primary Immunodeficiency Diseases · Phase 2
- Primary Myelofibrosis · Phase 2
Mechanism of action
- CytomegalovirusImmunity, passive
Cytomegalovirus immunity, passive
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- cmv-alt
- cmv ctls
- cmv pp65 specific t cells
- cmv specific adoptive t-cells
- cmv specific cytotoxic t lymphocytes
- cmv-specific t-cells
- donor-derived cmvpp65-specific t cells
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06909110 | Phase 1/Phase 2 (Phase 2) | Apr 30, 2025 | Stanford University |
| NCT05140187 | Phase 1 | Oct 15, 2021 | People's Liberation Army of China |
| NCT05089838 | Phase 1 | Jan 6, 2021 | Peking University |
| NCT04364178 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2020 | University of Pittsburgh |
| NCT04153279 | Phase 1 | Dec 1, 2019 | China Immunotech, Ludaopei Hospital |
| NCT04056533 | Phase 2 | Oct 1, 2019 | University of Cantabria |
| NCT03950414 | Phase 1 | Jul 31, 2019 | University of Wisconsin |
| NCT03798301 | Phase 1 | Jul 15, 2019 | University of Wisconsin |
| NCT03266640 | Phase 2 | May 1, 2018 | Medical College of Wisconsin, New York Medical College, University of Pennsylvania |
| NCT02982902 | Early Phase 1 (Phase 1) | Dec 1, 2016 | Case Western Reserve University |
| NCT03004261 | Phase 4 | Nov 1, 2016 | Jiao Tong University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT02985775 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2016 | Peking University |
| NCT03067155 | Phase 2 | Oct 1, 2016 | Ghent University |
| NCT02396134 | Phase 2 | May 21, 2015 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT02136797 | Phase 2 | May 1, 2014 | Atara Biotherapeutics, Cornell University |
| NCT02988258 | Phase 1 | Jul 1, 2013 | University of London |
| NCT01646645 | Phase 2 | Jul 1, 2012 | Atara Biotherapeutics, Cornell University |
| NCT01274377 | Phase 1 | Feb 1, 2011 | Duke University |
| NCT01239368 | Phase 1 | Oct 26, 2010 | Georgetown University, National Cancer Institute (NCI), Rutgers University |
| NCT01220895 | Phase 2 | Oct 1, 2010 | Kuur Therapeutics, University of Birmingham, University of London |
Showing 20 of 29 trials
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Organizations
Research & Development (34)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 4 | 1 | 2 | 1997 |
| Atara Biotherapeutics | For profit | 3 | 3 | 2 | 2007 |
| Cornell University | Academic/Hospital | 3 | 0 | 2 | 2007 |
| Duke University | Academic/Hospital | 3 | 3 | 1 | 2005 |
| University of London | Academic/Hospital | 3 | 1 | 3 | 2008 |
| City of Hope National Medical Center | Academic/Hospital | 2 | 2 | 2 | 1997 |
| Kuur Therapeutics | For profit | 2 | 2 | 2 | 2008 |
| Peking University | Academic/Hospital | 2 | 2 | 2 | 2016 |
| Pennsylvania State University | Academic/Hospital | 2 | 2 | 1 | 2007 |
| University of Birmingham | Academic/Hospital | 2 | 1 | 1 | 2009 |
| University of Wisconsin | Academic/Hospital | 2 | 2 | 1 | 2019 |
| Baylor University | Academic/Hospital | 1 | 1 | 1 | 2004 |
| BioAnaLab | For profit | 1 | 0 | 1 | 2008 |
| Case Western Reserve University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| China Immunotech | For profit | 1 | 0 | 1 | 2019 |
| Commitum AB | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Emas Pharma Ltd. | For profit | 1 | 0 | 1 | 2008 |
| Georgetown University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Ghent University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2016 |
34 organizations
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