eperisone
Small moleculeexperimental
Eperisone is an antispasmodic drug. — Wikipedia
Clinical trial activity
12 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
5
Phase 3
3
Phase 4
0
Earliest trial started Apr 1, 2006 (NCT00327730)
Timeline
Indications
Mechanism of action
- Voltage-gated calcium channelINHIBITOR
Voltage-gated calcium channel inhibitor
- Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D) ↗
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) ↗
- Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B) ↗
- Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-4 (CACNA2D4) ↗
- Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F) ↗
- Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E) ↗
- Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) ↗
- Voltage-dependent calcium channel gamma-7 subunit (CACNG7) ↗
- Voltage-dependent calcium channel gamma-5 subunit (CACNG5) ↗
- Voltage-dependent calcium channel gamma-2 subunit (CACNG2) ↗
- Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) ↗
- Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) ↗
- Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) ↗
- Voltage-dependent calcium channel gamma-4 subunit (CACNG4) ↗
- Voltage-dependent calcium channel gamma-8 subunit (CACNG8) ↗
- Voltage-dependent calcium channel gamma-3 subunit (CACNG3) ↗
- Voltage-dependent calcium channel gamma-6 subunit (CACNG6) ↗
- Voltage-dependent calcium channel gamma-1 subunit (CACNG1) ↗
- Voltage-gated T-type calcium channel alpha-1H subunit
- Voltage-gated calcium channel alpha2/delta subunit 1
- Voltage-gated L-type calcium channel alpha-1C subunit
- Voltage-gated N-type calcium channel alpha-1B subunit
- Voltage-gated L-type calcium channel alpha-1S subunit
- Voltage-gated L-type calcium channel alpha-1D subunit
- Voltage-gated calcium channel alpha2/delta subunit 2
- Voltage-gated P/Q-type calcium channel alpha-1A subunit
- Voltage-gated T-type calcium channel alpha-1G subunit
- Voltage-gated T-type calcium channel alpha-1I subunit
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Voltage-gated L-type calcium channel
- Voltage-gated T-type calcium channel
- Voltage-dependent L-type calcium channel subunit beta-2
- Voltage-dependent N-type calcium channel subunit alpha-1B/Voltage-dependent calcium channel subunit alpha-2/delta-1/Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b
- Voltage-dependent P/Q-type calcium channel alpha1A/alpha2delta/beta1b
- N-type calcium channel alpha-1b/alpha2delta-1/beta-1b
- L-type calcium channel alpha-1c/beta-2/alpha2delta-1
- Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel subunit alpha-1C/L-type calcium channel subunit beta-3/calcium channel subunit alpha-2/delta-1
Chemistry & pharmacology
Loading structure…
SMILES
CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1- Mol. weight
- 259.39 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaEperisone ↗
- ChEMBLCHEMBL1902981 ↗
Also known as
- 1-propanone, 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride
- (2rs)-1-(4-ethylphenyl)-2-methyl-3-(1-piperidyl)propan-1-one
- (2rs)-1-(4-ethylphenyl)-2-methyl-3-(1-piperidyl)propan-1-one
- 4-empp
- (4'-ethyl-2-methyl-3-piperidino)propiophenone
- dw1030
- e-0646
- eperison
- eperison
- eperisona
- eperisona
- eperisone
- eperisone
- eperisone
- eperisone
- eperisone
- eperisone
- eperisone
- eperisone
- (+/-)-eperisone
- epérisone
- epérisone
- eperisone hcl
- eperisone hcl
- eperisone hcl
- eperisone hydrochloride
- eperisone hydrochloride
- eperisone hydrochloride
- eperisonum
- eperisonum
- epirisone
- hcp1104
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06395155 | Phase 1 | Oct 26, 2023 | Chonbuk National University, Daehwa Pharmaceutical Co., Ltd. |
| NCT03337607 | N/A | Nov 13, 2017 | Ludwig Maximilians University, Zhejiang University |
| NCT03424707 | Phase 2 | Mar 4, 2016 | Daewon Pharmaceutical Co., Ltd. |
| NCT02380976 | Phase 1 | Oct 1, 2015 | Daewon Pharmaceutical Co., Ltd. |
| NCT02289274 | Phase 1 | Dec 1, 2014 | Navipharm Corporation, University of Ulsan |
| NCT02071381 | Phase 1 | Apr 1, 2014 | Daewon Pharmaceutical Co., Ltd. |
| NCT02040415 | Phase 3 | Mar 1, 2014 | Daewon Pharmaceutical Co., Ltd. |
| NCT01869985 | Phase 1 | Aug 1, 2013 | Hanmi Pharmaceutical |
| NCT01806818 | Phase 2 | Feb 1, 2013 | Hanmi Pharmaceutical, Yonsei University |
| NCT01306318 | N/A | Feb 1, 2011 | Eisai |
| NCT01300312 | Phase 3 | Feb 1, 2011 | Eisai |
| NCT00327730 | Phase 3 | Apr 1, 2006 | Eisai |
Showing 12 of 12 trials
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Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Daewon Pharmaceutical Co., Ltd. | For profit | 4 | 4 | 3 | 2014 |
| Eisai | For profit | 3 | 3 | 2 | 2006 |
| Hanmi Pharmaceutical | For profit | 2 | 2 | 2 | 2013 |
| Chonbuk National University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Daehwa Pharmaceutical Co., Ltd. | For profit | 1 | 1 | 1 | 2023 |
| Ludwig Maximilians University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Navipharm Corporation | For profit | 1 | 1 | 1 | 2014 |
| University of Ulsan | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Yonsei University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2017 |
10 organizations
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