tibolone
Trade name: xyvion
Small moleculeexperimental
Clinical trial activity
21 trials · 18 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
7
Phase 3
6
Phase 4
10
Earliest trial started Oct 1, 2000 (NCT00431431)
Timeline
Indications
Approved for
Studied for
- Amenorrhea · Phase 4
- Bone Diseases, Metabolic · Phase 4
- Breast Neoplasms · Phase 3
- Cholesterol, HDL · Phase 4
- Depression · Phase 4
- Endometriosis · Phase 4
- Hyperlipidemias · Phase 1
- Hypertension · Phase 1
- Major Depressive Disorder · Phase 1
- Menopause · Phase 4
- Osteoporosis · Phase 4
- Osteoporosis, Postmenopausal · Phase 2
- Postmenopause · Phase 4
- Quality of Life · Phase 4
- Sexual Dysfunction, Physiological · Phase 3
- Signs and Symptoms · Phase 3
- Vasomotor System · Phase 4
Mechanism of action
- Estrogen receptorAGONIST
ESR1 agonist
Chemistry & pharmacology
Loading structure…
SMILES
C#C[C@]1(O)CC[C@H]2[C@@H]3[C@H](C)CC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C- Mol. weight
- 312.45 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2103774 ↗
Also known as
- 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one
- 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one
- 19-norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7-alpha,17-alpha)-
- berenguer infale brand of tibolone
- boltin
- livial
- livial
- livial
- liviella
- liviella
- organon brand of tibolone
- org od14
- org od 14
- org od 14
- org od 14
- tibilone
- tibolona
- tibolona
- tibolone
- tibolone
- tibolone
- tibolone
- tibolone
- tibolone
- tibolone
- tibolone
- tibolonum
- tibolonum
- xyvion
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02393482 | Phase 4 | Jun 1, 2016 | University of Cagliari |
| NCT01764178 | Phase 1 | Jan 22, 2013 | JW Pharmaceutical, University of Ulsan |
| NCT01822288 | Phase 4 | Dec 1, 2012 | Far Eastern Memorial Hospital |
| NCT01368068 | Phase 4 | Jul 1, 2012 | Monash University, The Alfred Hospital |
| NCT01470092 | Phase 4 | Jul 1, 2012 | Monash University, The Alfred Hospital |
| NCT01543399 | N/A | Mar 1, 2012 | Federal University of Minas Gerais |
| NCT01679795 | N/A | Feb 1, 2012 | Federal University of Minas Gerais |
| NCT01239888 | Phase 1 | Jan 1, 2012 | Monash University, The Alfred Hospital |
| NCT00472004 | Phase 4 | Feb 1, 2006 | Pfizer |
| NCT00145522 | Phase 4 | Nov 1, 2005 | Solvay |
| NCT00809068 | Phase 4 | Aug 1, 2005 | Keogh Institute for Medical Research, University of Western Australia |
| NCT00299364 | Phase 3 | Sep 1, 2004 | Peking University, Schaper & Bruemmer GmbH & Co KG |
| NCT00165204 | Phase 2 | Apr 1, 2004 | Department of Defense, Harvard University |
| NCT00413764 | Phase 3 | Mar 23, 2004 | Merck |
| NCT00294463 | Phase 4 | Feb 1, 2003 | Erasmus University Rotterdam, Organon |
| NCT00725374 | Phase 3 | Dec 15, 2002 | Merck |
| NCT00431093 | Phase 4 | Nov 1, 2002 | Merck |
| NCT00408863 | Phase 3 | May 1, 2002 | Merck |
| NCT00745108 | Phase 3 | Oct 1, 2001 | Merck |
| NCT00519857 | Phase 3 | Jul 1, 2001 | Merck |
Showing 20 of 21 trials
Page 1 / 2
Organizations
Research & Development (18)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merck | For profit | 7 | 7 | 2 | 2000 |
| Monash University | Academic/Hospital | 3 | 3 | 2 | 2012 |
| The Alfred Hospital | Academic/Hospital | 3 | 0 | 2 | 2012 |
| Federal University of Minas Gerais | Academic/Hospital | 2 | 2 | 1 | 2012 |
| Department of Defense | Government | 1 | 0 | 1 | 2004 |
| Erasmus University Rotterdam | Academic/Hospital | 1 | 1 | 1 | 2003 |
| Far Eastern Memorial Hospital | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2004 |
| JW Pharmaceutical | For profit | 1 | 1 | 1 | 2013 |
| Keogh Institute for Medical Research | Academic/Hospital | 1 | 1 | 1 | 2005 |
| Organon | For profit | 1 | 0 | 1 | 2003 |
| Peking University | Academic/Hospital | 1 | 0 | 1 | 2004 |
| Pfizer | For profit | 1 | 1 | 1 | 2006 |
| Schaper & Bruemmer GmbH & Co KG | For profit | 1 | 1 | 1 | 2004 |
| Solvay | For profit | 1 | 1 | 1 | 2005 |
| University of Cagliari | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Ulsan | Academic/Hospital | 1 | 0 | 1 | 2013 |
| University of Western Australia | Academic/Hospital | 1 | 0 | 1 | 2005 |
18 organizations
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