mianserin
Trade name: Tolvon
Small moleculeexperimental
Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant that is used primarily in the treatment of depression in Europe and elsewhere in the world. It is a tetracyclic antidepressant (TeCA). Mianserin is closely related to mirtazapine, both chemically and in terms of its actions and effects, although there are significant differences between the two drugs. — Wikipedia
Clinical trial activity
3 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
2
Earliest trial started Jan 1, 2015 (NCT02374567)
Timeline
2010s
- Jan 1, 2015
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Serotonin 2b (5-HT2b) receptorANTAGONIST
HTR2B antagonist
- Alpha-2a adrenergic receptorANTAGONIST
ADRA2A antagonist
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCN2c3ccccc3Cc3ccccc3C2C1- Mol. weight
- 264.37 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL6437 ↗
- WikipediaMianserin ↗
- ChEMBLCHEMBL544428 ↗
- ChEMBLCHEMBL398435 ↗
Also known as
- 1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine
- 1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine
- bolvidon
- bolvidon
- mianserin
- mianserin
- mianserin
- mianserin
- mianserin
- mianserin
- mianserin
- mianserin
- mianserin
- (+/-)-mianserin
- mianserina
- mianserina
- mianserine
- mianserine
- mianserine
- mianserine hcl
- mianserine hydrochloride
- mianserin hcl
- mianserin hcl
- mianserin hcl
- mianserin hydrochloride
- mianserin hydrochloride
- mianserin hydrochloride
- mianserin hydrochloride
- mianserin hydrochloride
- mianserin hydrochloride
- mianserinum
- mianserinum
- mianseryna
- mianseryna
- norval
- norval
- org gb 94
- org gb 94
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05599126 | Phase 4 | Dec 31, 2022 | Jiao Tong University |
| NCT02761161 | Phase 4 | Mar 1, 2016 | Competence Centre for Transcultural Psychiatry, Danish Center for Sleep Medicine, Mental Health Services in the Capital Region, Denmark |
| NCT02374567 | Phase 3 | Jan 1, 2015 | Gottfried Wilhelm Leibniz Universität Hannover |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Competence Centre for Transcultural Psychiatry | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Danish Center for Sleep Medicine | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Gottfried Wilhelm Leibniz Universität Hannover | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Mental Health Services in the Capital Region, Denmark | Academic/Hospital | 1 | 1 | 1 | 2016 |
5 organizations
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