manidipine
Small moleculeexperimental
Clinical trial activity
5 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
2
Phase 4
2
Earliest trial started Feb 1, 2002 (NCT00157586)
Timeline
Indications
Approved for
Mechanism of action
- Voltage-gated T-type calcium channelANTAGONIST
Voltage-gated T-type calcium channel antagonist
- Voltage-gated L-type calcium channelANTAGONIST
Voltage-gated L-type calcium channel antagonist
Voltage-gated L-type calcium channel blocker
Also active against T-type calcium channels which may contribute to additional organ protective effects.
Chemistry & pharmacology
Loading structure…
SMILES
COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1- Mol. weight
- 610.71 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1085699 ↗
Also known as
- 2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
- cv 4093
- cv-4093
- franidipine
- manidipine
- manidipine
- manidipine
- manidipine
- manidipine
- manidipine
- manidipine
- (+/-)-manidipine
- manidipine 6300
- manidipine 6300
- manidipine dihydrochloride
- manidipine dihydrochloride
- manidipine dihydrochloride
- manidipine dihydrochloride
- manidipine dihydrochloride
- manidipine hcl
- manidipine hcl
- manidipine hcl
- manidipine hydrochloride
- manidipine hydrochloride
- manidipine, (+-)-isomer
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07091136 | Phase 2 | Aug 1, 2025 | Huazhong University of Science and Technology |
| NCT03106597 | Phase 4 | Aug 20, 2015 | Korea University, Takeda |
| NCT00741585 | Phase 4 | Sep 1, 2008 | University of Vigo |
| NCT00627952 | Phase 3 | Nov 1, 2007 | Chiesi, University of Erlangen-Nuremberg |
| NCT00157586 | Phase 3 | Feb 1, 2002 | Mario Negri Institute |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Chiesi | For profit | 1 | 0 | 1 | 2007 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Korea University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Mario Negri Institute | Academic/Hospital | 1 | 1 | 1 | 2002 |
| Takeda | For profit | 1 | 0 | 1 | 2015 |
| University of Erlangen-Nuremberg | Academic/Hospital | 1 | 1 | 1 | 2007 |
| University of Vigo | Academic/Hospital | 1 | 1 | 1 | 2008 |
7 organizations
Page 1 / 1