lersivirine
Small moleculeexperimental
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of HIV. RT is one of the most popular targets in the field of antiretroviral drug development. — Wikipedia
Clinical trial activity
12 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 2006 (NCT00348673)
Timeline
Indications
Studied for
Mechanism of action
- Reverse transcriptaseINHIBITOR
Reverse transcriptase inhibitor
Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCc1nn(CCO)c(CC)c1Oc1cc(C#N)cc(C#N)c1- Mol. weight
- 310.36 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
Also known as
- 5-((3,5-diethyl-1-(2-hydroxyethyl)(3,5-14c2)-1h-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitrile
- lersivirine
- lersivirine
- lersivirine
- lersivirine
- lersivirine
- uk453061
- uk 453061
- uk 453,061
- uk-453061
- uk-453061
- uk-453061
- uk-453,061
- uk-453,061
- uk-453,061
- uk453,061
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01603485 | Phase 1 | Jun 1, 2012 | Pfizer, ViiV Healthcare |
| NCT01254656 | Phase 2 | Feb 1, 2011 | Pfizer, ViiV Healthcare |
| NCT01220232 | Phase 1 | Nov 1, 2010 | Pfizer, ViiV Healthcare |
| NCT01230385 | Phase 1 | Oct 1, 2010 | Pfizer, ViiV Healthcare |
| NCT01099748 | Phase 1 | May 1, 2010 | Pfizer |
| NCT00925535 | Phase 1 | May 1, 2010 | Pfizer |
| NCT01050751 | Phase 1 | Feb 1, 2010 | Pfizer |
| NCT00936871 | Phase 1 | Jan 1, 2010 | Pfizer |
| NCT00823979 | Phase 2 | Mar 1, 2009 | Pfizer |
| NCT00824421 | Phase 2 | Feb 1, 2009 | Pfizer |
| NCT00784420 | Phase 1 | Sep 1, 2008 | Pfizer |
| NCT00348673 | Phase 2 | Feb 1, 2006 | Pfizer, ViiV Healthcare |
Showing 12 of 12 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Pfizer | For profit | 12 | 12 | 2 | 2006 |
| ViiV Healthcare | For profit | 5 | 0 | 2 | 2006 |
2 organizations
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