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ketone

Small moleculeexperimental

In organic chemistry, a ketone is an organic compound with the structure R−C(=O)−R', where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group −C(=O)−. The simplest ketone is acetone, with the formula (CH3)2CO. Many ketones are of great importance in biology and industry. Examples include many sugars (ketoses), many steroids, e.g., testosterone, and the solvent acetone. — Wikipedia

Clinical trial activity

76 trials · 55 clinical orgs · 0 marketing orgs

Phase 1
8
Phase 2
9
Phase 3
5
Phase 4
2

Earliest trial started Mar 1, 2015 (NCT02357550)

Timeline

2010s

  1. Jan 1, 2018

    Earliest Phase 1 Sponsor(trial)

2020s

  1. Jan 1, 2020

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetSupplementation

    supplementation

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • ketone
  • ketone

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06807918Phase 2/Phase 3 (Phase 3)Feb 28, 2026National Institute on Alcohol Abuse and Alcoholism (NIAAA), University of Pennsylvania
NCT07220122Early Phase 1 (Phase 1)Jan 10, 2026Johns Hopkins University
NCT07128524Phase 2Dec 1, 2025University of Maryland
NCT07224282Early Phase 1 (Phase 1)Nov 17, 2025University of Oklahoma
NCT07166965N/ANov 15, 2025Thomas Jefferson University
NCT07203521Phase 2Nov 1, 2025NeuroDawn Pharmaceutical Co., Ltd.
NCT07097506Phase 2Sep 26, 2025Washington University in St. Louis
NCT07166380Phase 1/Phase 2 (Phase 2)Sep 20, 2025NeuroDawn Pharmaceutical Co., Ltd.
NCT06937320Phase 2Jul 28, 2025Duke University
NCT07289165N/AJul 15, 2025NeuroEnergy Ventures, Inc.
NCT06815237Phase 2/Phase 3 (Phase 3)Mar 31, 2025National Institute on Alcohol Abuse and Alcoholism (NIAAA), University of Pennsylvania
NCT06559995Phase 2/Phase 3 (Phase 3)Dec 31, 2024National Institute on Alcohol Abuse and Alcoholism (NIAAA), University of Pennsylvania
NCT06655649Phase 1Dec 1, 2024HVMN, Johns Hopkins University, KETONE-IQ
NCT06687655Phase 1/Phase 2 (Phase 2)Dec 1, 2024HVMN, Johns Hopkins University, KETONE-IQ
NCT06588946N/ANov 30, 2024Heart and Stroke Foundation of Canada, McMaster University
NCT06685913N/ANov 11, 2024University of Exeter
NCT06653725Phase 2Nov 1, 2024Aalborg University, Aarhus University, University of Copenhagen, University of Southern Denmark, Viborg Regional Hospital
NCT06610344N/AOct 15, 2024University of Pennsylvania
NCT06418074N/ASep 30, 2024Gødstrup Hospital
NCT06578637N/ASep 20, 2024University of Pennsylvania, V Foundation
Showing 20 of 76 trials
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Organizations

Research & Development (55)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of PennsylvaniaAcademic/Hospital9922022
Aarhus UniversityAcademic/Hospital7722015
University of British ColumbiaAcademic/Hospital7512016
Ohio State UniversityAcademic/Hospital5512022
Johns Hopkins UniversityAcademic/Hospital3322024
McGill UniversityAcademic/Hospital3312020
McMaster UniversityAcademic/Hospital3312023
National Institute on Alcohol Abuse and Alcoholism (NIAAA)Government3012024
Stony Brook UniversityAcademic/Hospital3222015
University of Alabama, BirminghamAcademic/Hospital3312019
University of ExeterAcademic/Hospital3312022
Arla FoodsFor profit2012019
Augusta UniversityAcademic/Hospital2212016
Cairo UniversityAcademic/Hospital2212018
Gødstrup HospitalAcademic/Hospital2212024
Harvard UniversityAcademic/Hospital2122015
HVMNFor profit2022024
Katholieke Universiteit LeuvenAcademic/Hospital2212018
KETONE-IQFor profit2022024
Martinos Center for Biomedical ImagingAcademic/Hospital2012015
55 organizations
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