sofinicline
Small moleculeexperimental
Clinical trial activity
3 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Jan 1, 2007 (NCT00429091)
Timeline
2000s
- Jan 1, 2007
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
Neuronal acetylcholine receptor; alpha4/beta2 agonist
selectivity for the cytisine binding site on CHRNA4
Selectivity for the cytisine binding site on CHRNA4.
Chemistry & pharmacology
Loading structure…
SMILES
Clc1cc(N2C[C@@H]3CN[C@@H]3C2)cnc1Cl- Mol. weight
- 244.12 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL238465 ↗
Also known as
- 3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane
- a-422894.0
- a-422894.0
- abt-894
- abt-894
- abt-894
- abt-894
- sofinicline
- sofinicline
- sofinicline
- sofinicline
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00548925 | Phase 2 | Nov 1, 2007 | AbbVie |
| NCT00507936 | Phase 2 | Aug 1, 2007 | AbbVie |
| NCT00429091 | Phase 2 | Jan 1, 2007 | Abbott |
Showing 3 of 3 trials
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