imidafenacin
Small moleculeexperimental
Imidafenacin (INN) is a urinary antispasmodic of the anticholinergic class. It is used for the treatment of urinary incontinence and related bladder issues, especially in patients with benign prostatic hyperplasia or who have had prostate surgery. Unlike most related drugs, it is orally active but still shows a rapid onset of action, which makes it more convenient to administer. — Wikipedia
Clinical trial activity
6 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
4
Phase 3
3
Phase 4
2
Earliest trial started Oct 1, 2001 (NCT00212706)
Timeline
Indications
Approved for
Studied for
Mechanism of action
- Muscarinic acetylcholine receptor M1ANTAGONIST
Muscarinic acetylcholine receptor M1 antagonist
- Muscarinic acetylcholine receptor M3ANTAGONIST
Muscarinic acetylcholine receptor M3 antagonist
Active against M1 and M3, the M3 receptor is proposed to mediate the therapeutic effect in the bladder.
Chemistry & pharmacology
Loading structure…
SMILES
Cc1nccn1CCC(C(N)=O)(c1ccccc1)c1ccccc1- Mol. weight
- 319.41 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaImidafenacin ↗
- ChEMBLCHEMBL53366 ↗
Also known as
- imidafenacin
- imidafenacin
- imidafenacin
- imidafenacin
- imidafenacin
- imidafenacin
- imidafenacin
- imidafenacin
- imidafenacin
- krp 197
- krp 197
- krp-197
- krp-197
- krp-197
- krp-197
- krp-197
- ono-8025
- ono-8025
- uritos
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03575702 | Phase 3 | Jul 18, 2016 | R-Pharm, Synergy Research |
| NCT02294396 | Phase 4 | Oct 1, 2014 | Astellas |
| NCT01578304 | Phase 4 | Dec 1, 2010 | Kyorin Pharma, LG, Sungkyunkwan University |
| NCT00512785 | Phase 3 | Aug 1, 2007 | Kyorin Pharma, Ono Pharmaceuticals |
| NCT00212732 | Phase 3 | Oct 1, 2003 | Ono Pharmaceuticals |
| NCT00212706 | Phase 2 | Oct 1, 2001 | Ono Pharmaceuticals |
Showing 6 of 6 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ono Pharmaceuticals | For profit | 3 | 3 | 2 | 2001 |
| Kyorin Pharma | For profit | 2 | 0 | 2 | 2007 |
| Astellas | For profit | 1 | 1 | 1 | 2014 |
| LG | For profit | 1 | 1 | 1 | 2010 |
| R-Pharm | For profit | 1 | 1 | 1 | 2016 |
| Sungkyunkwan University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Synergy Research | For profit | 1 | 0 | 1 | 2016 |
7 organizations
Page 1 / 1