hypericum perforatum
Botanicalexperimental
Hypericum perforatum, commonly known as St. John's wort, is a flowering plant in the family Hypericaceae. It is a hairless, perennial herb with woody roots, yellow flowers marked by black glands, and leaves that appear perforated due to translucent glands, producing thousands of seeds per plant. — Wikipedia
Clinical trial activity
35 trials · 44 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
16
Phase 3
10
Phase 4
5
Earliest trial started Dec 1, 1998 (NCT00005013)
Timeline
Indications
Approved for
Studied for
- Anxiety · Phase 4
- Anxiety Disorders · Phase 2/Phase 3
- Attention Deficit Disorder with Hyperactivity · Phase 3
- Breast Neoplasms · Phase 3
- Contraception · Phase 4
- Depression · Phase 4
- Diabetes Mellitus, Type 2 · Phase 1
- Drug Interactions · Phase 1
- Drugs, Investigational · Phase 4
- Fatigue · Phase 3
- Head and Neck Neoplasms · Phase 3
- Healthy Volunteers · Phase 4
- Hepatitis C · Phase 1
- Hot Flashes · Phase 2
- Irritable Bowel Syndrome · Phase 2
- Kidney Neoplasms · Phase 3
- Leukemia · Phase 3
- Lung Diseases · Phase 3
- Lymphoma · Phase 3
- Major Depressive Disorder · Phase 2
- Menopause · Phase 3
- Mental Health · Phase 2/Phase 3
- Multiple Myeloma · Phase 3
- Myelodysplastic Syndromes · Phase 3
- Myeloproliferative Disorders · Phase 3
- Neoplasms · Phase 3
- Obsessive-Compulsive Disorder · Phase 2
- Pain · Phase 4
- Peritoneal Neoplasms · Phase 3
- Phobic Disorders · Phase 2
- Precancerous Conditions · Phase 3
- Raynaud Disease · Phase 3
- Smoking · Phase 2
- Tobacco Use Disorder · Phase 2
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaHypericum perforatum ↗
- NCATSUFH8805FKA ↗
- ChEMBLCHEMBL2108102 ↗
- WikipediaHypericum ↗
Also known as
- common st johnswort flowering top
- common st. john's wort flowering top
- common st. johnswort flowering top
- common st. john's wort herb
- guanyejinsitao
- hiperico
- hyperici herba
- hypericum
- hypericum
- hypericum nachitschevanicum flowering top
- hypericum perforatum
- hypericum perforatum flowering top
- hypoxis hemerocallidea root extract
- klamath weed flowering top
- klamathweed flowering top
- saint johns wort
- sedariston
- st john's wort
- st john's wort
- st johns wort
- st. john's wort
- st. john's wort
- st. john's wort
- st. johns wort
- st. johnswort flowering top
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07012278 | N/A | Jun 25, 2025 | Sakarya University |
| NCT04683263 | N/A | Jun 1, 2019 | Clinica Quirón Salud, Córdoba, Hospital QuiroSalud Barcelona, J. Uriach and Company |
| NCT03796377 | Phase 1 | Feb 13, 2019 | Bayer, University of Bern |
| NCT03783819 | N/A | Feb 4, 2019 | University of Split |
| NCT03482817 | Phase 1 | Feb 5, 2018 | Max Zeller Soehne AG |
| NCT02840331 | Phase 3 | Oct 1, 2016 | University of Tuebingen |
| NCT02862236 | Phase 4 | Oct 1, 2016 | Beer Yaakov and Ness Ziona Mental Health Center, Israel Institute of Technology, Technion University |
| NCT02505191 | Phase 1 | Nov 1, 2015 | Max Zeller Soehne AG |
| NCT01921881 | Phase 1 | Sep 30, 2013 | University of Southern Denmark |
| NCT01726764 | Phase 1 | Jan 1, 2013 | University of Southern Denmark |
| NCT01663922 | Phase 1 | Aug 1, 2012 | St Stephens Aids Trust, University of Liverpool, University of Turin |
| NCT01481025 | Phase 3 | Nov 1, 2011 | Federal University of Health Science of Porto Alegre, Phytopharm |
| NCT01330589 | N/A | Apr 1, 2011 | H. G. Barsumian Memorial Fund, Lancaster General Hospital, Lancaster General Research Institute, Louise von Hess Medical Research Institute |
| NCT04315597 | Phase 3 | Mar 3, 2009 | Bayer |
| NCT00557427 | Phase 4 | Jan 1, 2009 | Rafa Laboratories, Tel Aviv University |
| NCT00782080 | Phase 3 | Jul 1, 2008 | Johannes Gutenburg University, Steiner Arzneimittel |
| NCT00451516 | Phase 2 | Mar 1, 2007 | University of Queensland |
| NCT00351117 | Phase 3 | Mar 1, 2007 | University of Western Ontario |
| NCT00110136 | Phase 2 | Mar 1, 2006 | National Cancer Institute (NCI), Wake Forest University |
| NCT00587860 | Phase 2 | Feb 1, 2006 | Mayo Clinic |
Showing 20 of 35 trials
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Organizations
Research & Development (44)
44 organizations
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