fallypride
Small moleculeexperimental
Fallypride is a high-affinity dopamine D2/D3 receptor antagonist used in medical research, usually in the form of fallypride (18F) as a positron emission tomography (PET) radiotracer in human studies. — Wikipedia
Clinical trial activity
6 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
3
Phase 3
1
Phase 4
0
Earliest trial started Jun 17, 2003 (NCT00062946)
Timeline
Indications
Mechanism of action
- Dopamine D3 receptorINHIBITOR
DRD3 inhibitor
- Dopamine D2 receptorINHIBITOR
DRD2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC- Mol. weight
- 364.46 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaFallypride ↗
- ChEMBLCHEMBL392158 ↗
Also known as
- 5-(3-fluoropropyl)-2,3-dimethoxy-n-(((2s)-1-(2-propenyl)-2-pyrrolidinyl)methyl)benzamide
- fallypride
- fallypride
- fallypride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05834478 | Phase 3 | Dec 31, 2023 | Emory University, National Institute on Drug Abuse (NIDA) |
| NCT03648892 | Early Phase 1 (Phase 1) | Sep 21, 2018 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| NCT02824666 | Phase 1 | Jun 1, 2016 | Braeburn Pharmaceuticals |
| NCT00846040 | Phase 2 | Feb 13, 2009 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| NCT00801827 | Phase 1 | Jan 1, 2007 | Vanderbilt University |
| NCT00062946 | Phase 2 | Jun 17, 2003 | National Institute of Mental Health (NIMH) |
Showing 6 of 6 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 2 | 2 | 2 | 2009 |
| Braeburn Pharmaceuticals | For profit | 1 | 1 | 1 | 2016 |
| Emory University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| National Institute of Mental Health (NIMH) | Government | 1 | 1 | 1 | 2003 |
| National Institute on Drug Abuse (NIDA) | Government | 1 | 0 | 1 | 2023 |
| Vanderbilt University | Academic/Hospital | 1 | 1 | 1 | 2007 |
6 organizations
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