gsk-690693
Small moleculeexperimental
Clinical trial activity
2 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2007 (NCT00493818)
Timeline
2000s
- Jan 1, 2007
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Serine/threonine-protein kinase AKTINHIBITOR
Serine/threonine-protein kinase AKT inhibitor
- cAMP-dependent protein kinase (PKA)INHIBITOR
cAMP-dependent protein kinase (PKA) inhibitor
- Protein kinase C (PKC)INHIBITOR
Protein kinase C (PKC) inhibitor
- Serine/threonine-protein kinase D3 (PRKD3) ↗
- Protein kinase C iota type (PRKCI) ↗
- Protein kinase C alpha type (PRKCA) ↗
- Protein kinase C gamma type (PRKCG) ↗
- Protein kinase C delta type (PRKCD) ↗
- Protein kinase C beta type (PRKCB) ↗
- Protein kinase C zeta type (PRKCZ) ↗
- Protein kinase C epsilon type (PRKCE) ↗
- Protein kinase C eta type (PRKCH) ↗
- Serine/threonine-protein kinase D1 (PRKD1) ↗
- Protein kinase C theta type (PRKCQ) ↗
- Protein kinase C zeta
- Protein kinase C epsilon
- Protein kinase C gamma
- Protein kinase C nu
- Protein kinase C iota
- Protein kinase C mu
- Protein kinase C eta
- Protein kinase C alpha
- Protein kinase C beta
- Protein kinase C delta
- Protein kinase C theta
- Protein kinase C, PKC; classical/novel
- PKC alpha and beta-2
- Protein kinase C iota type/zeta type
Chemistry & pharmacology
Loading structure…
SMILES
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21- Mol. weight
- 425.49 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL494089 ↗
Also known as
- gsk690693
- gsk690693
- gsk690693
- gsk-690693
- gsk-690693
- gsk-690693
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00666081 | Phase 1 | Apr 1, 2008 | GlaxoSmithKline |
| NCT00493818 | Phase 1 | Apr 1, 2007 | GlaxoSmithKline |
Showing 2 of 2 trials
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Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 2 | 2 | 1 | 2007 |
1 organizations
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