glufosfamide

Small moleculeexperimental

Glufosfamide, also known as glucophosphamide, D-glucose isophosphoramide mustard, D-19575 is an experimental cytotoxic chemotherapeutic agent for treatment of malignancies. — Wikipedia

Clinical trial activity

9 trials · 22 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
9
Phase 3
2
Phase 4
0

Earliest trial started Dec 1, 1999 (NCT00005053)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 2 Sponsor(trial)

2000s

  1. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2004

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

  • DNACROSS-LINKING AGENT

    DNA cross-linking agent

  • DNADISRUPTING AGENT

    DNA disrupting agent

    Alkylating agent

Chemistry & pharmacology

Loading structure…

SMILES

O=P(NCCCl)(NCCCl)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Mol. weight
383.17 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • beta-d-glc-ipm
  • beta-d-glucosyl-ifosfamide mustard
  • beta-d-glucosylisophosphoramide mustard
  • d 19575
  • d-19575
  • glucosyl-ifosfamide mustard
  • glufosfamide
  • glufosfamide
  • glufosfamide
  • glufosfamide

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT01954992Phase 3Sep 1, 2013Eleison Pharmaceuticals
NCT00441467Phase 2Mar 1, 2007Eleison Pharmaceuticals, New York Medical College, Premiere Oncology, Stanford University, Threshold Pharmaceuticals, University of Arizona, University of New Mexico, University of South Florida, Washington University in St. Louis
NCT00435578Phase 2Feb 1, 2007California Cancer Center, Threshold Pharmaceuticals, University of South Florida, Wayne State University
NCT00442598Phase 2Jan 1, 2007California Cancer Center, Eleison Pharmaceuticals, Gabrail Cancer Center, Harrington Cancer Center, Indiana University, New Mexico Cancer Care Alliance, Premiere Oncology, University of Arizona, University of California, Irvine, University of Louisville
NCT00102752Phase 1/Phase 2 (Phase 2)Dec 1, 2004PPD, Threshold Pharmaceuticals
NCT00099294Phase 3Sep 1, 2004PPD, Threshold Pharmaceuticals
NCT00014300Phase 2Jan 1, 2001Erasmus University Rotterdam, European Organisation for Research and Treatment of Cancer
NCT00005055Phase 2Jan 1, 2000Centre Georges Francois Leclerc, European Organisation for Research and Treatment of Cancer
NCT00005053Phase 2Dec 1, 1999European Organisation for Research and Treatment of Cancer, University of Ioannina
Showing 9 of 9 trials
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Organizations

Research & Development (22)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Threshold PharmaceuticalsFor profit4322004
Eleison PharmaceuticalsFor profit3322007
European Organisation for Research and Treatment of CancerAcademic/Hospital3311999
California Cancer CenterAcademic/Hospital2012007
PPDFor profit2022004
Premiere OncologyFor profit2012007
University of ArizonaAcademic/Hospital2012007
University of South FloridaAcademic/Hospital2012007
Centre Georges Francois LeclercAcademic/Hospital1012000
Erasmus University RotterdamAcademic/Hospital1012001
Gabrail Cancer CenterAcademic/Hospital1012007
Harrington Cancer CenterAcademic/Hospital1012007
Indiana UniversityAcademic/Hospital1012007
New Mexico Cancer Care AllianceAcademic/Hospital1012007
New York Medical CollegeAcademic/Hospital1012007
Stanford UniversityAcademic/Hospital1012007
University of California, IrvineAcademic/Hospital1012007
University of IoanninaAcademic/Hospital1011999
University of LouisvilleAcademic/Hospital1012007
University of New MexicoAcademic/Hospital1012007
22 organizations
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