gadoxetate disodium
Trade name: eovist
Small moleculeapproved
Approved
Jul 3, 2008
Gadoxetic acid is a gadolinium-based MRI contrast agent. Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals. — Wikipedia
Clinical trial activity
17 trials · 22 clinical orgs · 1 marketing orgs
Phase 1
4
Phase 2
4
Phase 3
2
Phase 4
6
Earliest trial started Oct 1, 2006 (NCT01420211)
Timeline
Indications
Approved for
Studied for
- Arteries · Phase 4
- Carcinoma, Hepatocellular · Phase 4
- Cognition · Phase 4
- Colorectal Neoplasms · Phase 4
- Contrast Media · Phase 4
- Fibrosis · Phase 4
- Liver · Phase 1/Phase 2
- Liver Diseases · Phase 3
- Liver Neoplasms · Phase 1
- Magnetic Resonance Imaging · Phase 3
- Motor Activity · Phase 4
- Neoplasm Metastasis · Phase 4
- Pharmacokinetics · Phase 1/Phase 2
- Prostatic Neoplasms · Phase 2
- Prostatic Neoplasms, Castration-Resistant · Early Phase 1
- Sports Medicine · Phase 1/Phase 2
Mechanism of action
- Unspecified targetOTHER
Unknown
Approval history
- approvedJul 3, 2008
Chemistry & pharmacology
- Mol. weight
- 684.78 g/mol
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaGadoxetic acid ↗
- ChEMBLCHEMBL2221312 ↗
- ChEMBLCHEMBL2103740 ↗
- ChEMBLCHEMBL1201768 ↗
Also known as
- disodium gadoxetate
- eovist
- eovist
- eovist
- eovist
- eovist
- eovist
- gadolinium (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanoic acid disodium salt
- gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid
- gadolinium ethoxybenzyl dtpa
- gadoxetate
- gadoxetate
- gadoxetate
- gadoxetate
- gadoxetate disodium
- gadoxetate disodium
- gadoxetate disodium
- gadoxetate disodium
- gadoxetate disodium
- gadoxetate disodium
- gadoxetic acid
- gadoxetic acid
- gadoxetic acid
- gadoxetic acid
- gadoxetic acid
- gadoxetic acid
- gadoxetic acid disodium
- gd-eob-dtpa
- gd-eob-dtpa
- gd-eob-dtpa
- gd-eob-dtpa
- gd-eob-dtpa
- primovist
- primovist
- primovist
- primovist
- zk-139834
- zk-139834
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04973007 | Phase 4 | Jun 22, 2021 | Bracco, National Cancer Institute (NCI), University of Colorado, Denver |
| NCT04373564 | Phase 4 | Jul 1, 2020 | Bayer, Bracco, General Electric, Guerbet, IQVIA |
| NCT03892681 | N/A | Apr 30, 2019 | Yonsei University |
| NCT03960788 | Early Phase 1 (Phase 1) | Jan 2, 2018 | University of Cincinnati |
| NCT02854371 | Phase 4 | Aug 1, 2016 | National Research Foundation of Korea, Seoul National University |
| NCT02431598 | Phase 4 | Jun 1, 2015 | Duke University, University of California, San Diego, University of Wisconsin |
| NCT02084628 | Phase 3 | Feb 1, 2015 | Bayer |
| NCT02156739 | N/A | Oct 1, 2014 | University of Texas at Houston |
| NCT01968629 | Early Phase 1 (Phase 1) | Dec 1, 2013 | Harvard University |
| NCT01867424 | Phase 2 | May 14, 2013 | National Cancer Institute (NCI) |
| NCT01575574 | Phase 4 | Jul 1, 2012 | University of Barcelona |
| NCT01522209 | N/A | Dec 1, 2011 | University of Hamburg |
| NCT01082224 | N/A | Dec 1, 2010 | American College of Radiology, National Cancer Institute (NCI), Tufts University |
| NCT02578602 | Phase 1 | Oct 1, 2010 | National Cancer Institute (NCI), University of Southern California |
| NCT00908596 | Phase 4 | May 1, 2009 | Bayer |
| NCT00526188 | Phase 3 | Aug 1, 2007 | Bayer |
| NCT01420211 | Phase 1/Phase 2 (Phase 2) | Oct 1, 2006 | University of Greifswald |
Showing 17 of 17 trials
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Organizations
Research & Development (22)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bayer | For profit | 4 | 3 | 2 | 2007 |
| National Cancer Institute (NCI) | Government | 4 | 1 | 4 | 2010 |
| Bracco | For profit | 2 | 0 | 1 | 2020 |
| American College of Radiology | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Duke University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| General Electric | For profit | 1 | 0 | 1 | 2020 |
| Guerbet | For profit | 1 | 1 | 1 | 2020 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| IQVIA | For profit | 1 | 0 | 1 | 2020 |
| National Research Foundation of Korea | Government | 1 | 0 | 1 | 2016 |
| Seoul National University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Tufts University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of Barcelona | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of California, San Diego | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of Cincinnati | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Colorado, Denver | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Greifswald | Academic/Hospital | 1 | 1 | 1 | 2006 |
| University of Hamburg | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Southern California | Academic/Hospital | 1 | 1 | 1 | 2010 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2014 |
22 organizations
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