fospropofol
Trade name: lusedra
Small moleculeapproved
Approved
Dec 8, 2008
Fospropofol (INN), often used as the disodium salt is an intravenous sedative-hypnotic agent. It is currently approved for use in sedation of adult patients undergoing diagnostic or therapeutic procedures such as endoscopy. — Wikipedia
Clinical trial activity
25 trials · 17 clinical orgs · 1 marketing orgs
Phase 1
3
Phase 2
10
Phase 3
8
Phase 4
7
Earliest trial started Jun 1, 2002 (NCT00209521)
Timeline
Indications
Approved for
Studied for
- Anesthesia · Phase 4
- Angioplasty · Phase 3
- Arthroscopy · Phase 3
- Bronchoscopy · Phase 3
- Bunion · Phase 3
- Carpal Tunnel Syndrome · Phase 3
- Catheters · Phase 3
- Colonic Polyps · Phase 3
- Colonoscopy · Phase 3
- Coronary Artery Bypass · Phase 2
- Coronary Artery Disease · Phase 2
- General Surgery · Phase 4
- Geriatrics · Phase 4
- Intubation · Phase 2
- Lactation Disorders · Phase 1
- Orthopedic Procedures · Phase 4
- Osteotomy · Phase 3
- Pain · Phase 4
- Pharmacological and Toxicological Phenomena · Phase 4
- Procedural Sedation · Phase 4
- Respiration, Artificial · Phase 2
Mechanism of action
- GABA-A receptorAGONIST
GABA-A receptor agonist
- Unspecified targetOTHER
Unknown
Approval history
- approvedDec 8, 2008
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)c1cccc(C(C)C)c1OCOP(=O)(O)O- Mol. weight
- 288.28 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL1201766 ↗
- WikipediaFospropofol ↗
- ChEMBLCHEMBL2021422 ↗
Also known as
- aquavan
- aquavan
- aquavan
- fospropofol
- fospropofol
- fospropofol
- fospropofol
- fospropofol
- fospropofol
- fospropofol
- fospropofol
- fospropofol disodium
- fospropofol disodium
- fospropofol disodium
- fospropofol disodium
- fospropofol disodium
- fospropofol disodium
- fospropofol sodium
- fospropofol sodium
- fospropofol sodium
- fospropofol sodium
- fospropofol sodium
- gpi15715
- gpi 15715
- lusedra
- lusedra
- lusedra
- lusedra
- lusedra
- lusedra
- methanol, (2,6-bis(1-methylethyl)phenoxy)-, dihydrogen phosphate, disodium salt
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06573489 | Phase 4 | Sep 15, 2024 | Huazhong University of Science and Technology |
| NCT06251999 | Phase 4 | Aug 1, 2024 | Jiao Tong University |
| NCT06344325 | Phase 4 | May 1, 2024 | Huazhong University of Science and Technology |
| NCT06261996 | N/A | Feb 12, 2024 | Henan Provincal People's Hospital |
| NCT01378754 | N/A | Jun 1, 2011 | University of Kansas |
| NCT01195103 | Phase 4 | Feb 1, 2011 | Eisai, Mayo Clinic |
| NCT01289483 | N/A | Feb 1, 2011 | Eisai, University of Rochester |
| NCT01308541 | Phase 1 | Jan 1, 2011 | Eisai |
| NCT01260142 | Phase 4 | Nov 1, 2010 | Eisai |
| NCT01309984 | Phase 1 | Nov 1, 2010 | Eisai |
| NCT01401049 | Phase 4 | Aug 1, 2010 | Eisai, New York University |
| NCT01127438 | Phase 4 | Apr 1, 2010 | Eisai |
| NCT01271569 | Phase 1 | Mar 1, 2010 | Sichuan University |
| NCT00327392 | Phase 2/Phase 3 (Phase 3) | May 1, 2006 | Eisai |
| NCT00306722 | Phase 3 | Apr 1, 2006 | Eisai |
| NCT00261599 | Phase 3 | Mar 1, 2006 | Eisai |
| NCT00125398 | Phase 2 | Jul 1, 2005 | Eisai |
| NCT00125424 | Phase 2/Phase 3 (Phase 3) | Jul 1, 2005 | Eisai |
| NCT00209599 | Phase 2 | Feb 1, 2005 | Covance, Eisai, PPD, Quest Pharmaceutical Services |
| NCT00209560 | Phase 3 | Oct 1, 2004 | Covance, Eisai, PPD |
Showing 20 of 25 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Eisai | For profit | 19 | 16 | 5 | 2002 |
| PPD | For profit | 6 | 0 | 2 | 2002 |
| Covance | For profit | 4 | 0 | 2 | 2004 |
| Bio Analytical Research Corporation | For profit | 2 | 0 | 2 | 2003 |
| CaligorRx, Inc. | For profit | 2 | 0 | 2 | 2003 |
| Huazhong University of Science and Technology | Academic/Hospital | 2 | 2 | 1 | 2024 |
| MDS Pharma | For profit | 2 | 0 | 2 | 2003 |
| Quest Pharmaceutical Services | For profit | 2 | 0 | 2 | 2004 |
| Henan Provincal People's Hospital | Academic/Hospital | 1 | 1 | 1 | 2024 |
| HHI Clinical Research | For profit | 1 | 0 | 1 | 2003 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2011 |
| New York University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Sichuan University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Theorem Clinical Research | For profit | 1 | 0 | 1 | 2003 |
| University of Kansas | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Rochester | Academic/Hospital | 1 | 1 | 1 | 2011 |
17 organizations
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