fosbretabulin

Small moleculeexperimental

Fosbretabulin is a microtubule destabilizing experimental drug, a type of vascular-targeting agent, a drug designed to damage the vasculature of cancer tumours causing central necrosis. It is a derivative of combretastatin. It is formulated as the salts fosbretabulin disodium and fosbretabulin tromethamine. — Wikipedia

Clinical trial activity

18 trials · 15 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Jul 1, 1998 (NCT00003698)

Timeline

1990s

Jan 1, 1998
Earliest Phase 1 Sponsor(trial)

2000s

Jan 1, 2003
Earliest Phase 2 Sponsor(trial)

2010s

Jan 1, 2015
Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc(/C=C\c2cc(OC)c(OC)c(OC)c2)cc1OP(=O)(O)O

Mol. weight: 396.33 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Prodrug

Sources

Also known as

1-(3,4,5-trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene
2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenyl dihydrogen phosphate
3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene
ca4dp
ca4dp
ca4dp
combretastatin a4
combretastatin a-4
combretastatin a-4 disodium phosphate
combretastatin a-4 phosphate
combretastatin a-4 phosphate
combretastatin a4 phosphate
combretastatin a4 phosphate
combretastatin a4 phosphate
crc 87-09
crc-98-09
deoxycombretastatin a-4
fosbretabulin
fosbretabulin
fosbretabulin
fosbretabulin
fosbretabulin
fosbretabulin disodium
fosbretabulin disodium
fosbretabulin disodium
fosbretabulin tromethamine
fosbretabulin tromethamine
isocombretastatin a-4
nsc 817373
nsc-817373
phenol, 2-methoxy-5-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-,1-(dihydrogen phosphate)
phenol, 2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, dihydrogen phosphate
zybrestat
zybrestat

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT03014297	Phase 1	Mar 6, 2017	University of Kentucky
NCT02641639	Phase 2/Phase 3 (Phase 3)	Jun 1, 2016	Mateon Therapeutics
NCT01701349	Phase 3	Mar 1, 2015	Mateon Therapeutics, University of Milan, University of Pennsylvania, Yale University
NCT02279602	Phase 2	Dec 1, 2014	Mateon Therapeutics
NCT02132468	Phase 2	Sep 1, 2014	Mateon Therapeutics
NCT02055690	Phase 1/Phase 2 (Phase 2)	Sep 1, 2014	East and North Hertfordshire NHS Trust, Mateon Therapeutics, Novartis, The Christie NHS Foundation Trust
NCT01305213	Phase 2	Mar 1, 2011	National Cancer Institute (NCI), NRG Oncology
NCT01052363	Phase 1	Jan 1, 2010	West Virginia University
NCT01023295	Phase 2	Jul 1, 2009	Mateon Therapeutics
NCT00653939	Phase 2	Mar 1, 2008	Mateon Therapeutics
NCT00395434	Phase 1	Sep 1, 2006	Inova Health System, Mateon Therapeutics
NCT01423149	Phase 2	Mar 1, 2005	Mateon Therapeutics
NCT00113438	Phase 2	Mar 1, 2005	Mateon Therapeutics
NCT00077103	Phase 1/Phase 2 (Phase 2)	Nov 1, 2003	Case Western Reserve University, National Cancer Institute (NCI)
NCT01570790	Phase 1/Phase 2 (Phase 2)	May 1, 2003	Johns Hopkins University
NCT00060242	Phase 2	Feb 1, 2003	Case Western Reserve University, National Cancer Institute (NCI)
NCT00003768	Phase 1	Sep 1, 1998	Case Western Reserve University, National Cancer Institute (NCI)
NCT00003698	Phase 1	Jul 1, 1998	Inova Health System, University of Glasgow

Showing 18 of 18 trials

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Organizations

Research & Development (15)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Mateon Therapeutics	For profit	10	9	3	2005
National Cancer Institute (NCI)	Government	4	1	2	1998
Case Western Reserve University	Academic/Hospital	3	3	2	1998
Inova Health System	Academic/Hospital	2	0	1	1998
East and North Hertfordshire NHS Trust	Academic/Hospital	1	0	1	2014
Johns Hopkins University	Academic/Hospital	1	1	1	2003
Novartis	For profit	1	0	1	2014
NRG Oncology	Academic/Hospital	1	0	1	2011
The Christie NHS Foundation Trust	Academic/Hospital	1	1	1	2014
University of Glasgow	Academic/Hospital	1	1	1	1998
University of Kentucky	Academic/Hospital	1	1	1	2017
University of Milan	Academic/Hospital	1	0	1	2015
University of Pennsylvania	Academic/Hospital	1	0	1	2015
West Virginia University	Academic/Hospital	1	1	1	2010
Yale University	Academic/Hospital	1	0	1	2015

15 organizations

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