calcium hydroxide
Small moleculeexperimental
Calcium hydroxide (traditionally called slaked lime) is an inorganic compound with the chemical formula Ca(OH)2. It is a colorless crystal or white powder and is produced when quicklime (calcium oxide) is mixed with water. Annually, approximately 125 million tons of calcium hydroxide are produced worldwide. — Wikipedia
Clinical trial activity
78 trials · 44 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
14
Phase 3
17
Phase 4
6
Earliest trial started May 1, 2007 (NCT00472173)
Timeline
Indications
Approved for
Studied for
- Apexification · Phase 2/Phase 3
- Bacterial Infections · Early Phase 1
- Biomarkers · Early Phase 1
- Bromelains · Early Phase 1
- Calcium Hydroxide · Phase 4
- Colorectal Neoplasms · Phase 4
- Cystine · Early Phase 1
- Dental Caries · Phase 4
- Dental Prosthesis · Phase 2/Phase 3
- Dental Pulp · Phase 4
- Dental Pulp Capping · Phase 4
- Dental Pulp Cavity · Phase 3
- Dental Pulp Diseases · Phase 2/Phase 3
- Dental Pulp Exposure · Phase 2/Phase 3
- Dental Pulp Necrosis · Phase 3
- Dentin · Phase 4
- Drug Delivery Systems · Phase 2/Phase 3
- Drugs, Investigational · Phase 2
- Endodontics · Phase 4
- Gastrointestinal Microbiome · Phase 2/Phase 3
- General Surgery · Phase 2
- Infections · Phase 4
- Inflammation · Early Phase 1
- Minerals · Phase 4
- Nanoparticles · Phase 2
- Obturator Nerve · Phase 2
- Pain · Phase 2
- Patient Reported Outcome Measures · Phase 4
- Periapical Diseases · Phase 2
- Periapical Periodontitis · Phase 3
- Periodontitis · Phase 2/Phase 3
- Postoperative Complications · Phase 2
- Postoperative Pain · Phase 4
- Prostatic Neoplasms · Phase 2
- Pulpitis · Phase 2/Phase 3
- Retreatment · Phase 2
- Symptom Flare Up · Phase 2
- Tooth · Phase 3
- Tooth Abnormalities · Phase 2
- Tooth, Nonvital · Phase 2
- Tooth Root · Phase 2
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Loading structure…
SMILES
[Ca+2].[OH-].[OH-]- Mol. weight
- 74.09 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCalcium hydroxide ↗
- ChEMBLCHEMBL2106388 ↗
Also known as
- calcium hydroxide
- calcium hydroxide
- calcium hydroxide
- calcium hydroxide
- calcium hyroxide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07239739 | N/A | Dec 15, 2025 | College of Physicians and Surgeons Pakistan |
| NCT07236567 | N/A | Dec 1, 2025 | Al Azhar University |
| NCT07262554 | Phase 2 | Nov 15, 2025 | Alexandria University |
| NCT07183514 | N/A | Sep 20, 2025 | University of Health Sciences Lahore |
| NCT07194837 | N/A | Sep 19, 2025 | Al Azhar University |
| NCT07071675 | N/A | Sep 1, 2025 | Minia University |
| NCT07101029 | Early Phase 1 (Phase 1) | Aug 31, 2025 | Cairo University |
| NCT07141459 | N/A | Aug 18, 2025 | Al Azhar University |
| NCT06755502 | N/A | Aug 8, 2025 | Cairo University |
| NCT07252258 | N/A | Jul 15, 2025 | College of Physicians and Surgeons Pakistan |
| NCT07075055 | N/A | Jul 1, 2025 | Minia University |
| NCT06821763 | Phase 2/Phase 3 (Phase 3) | May 1, 2025 | Margalla Institute of Health Sciences |
| NCT06625645 | N/A | Jan 1, 2025 | Cairo University |
| NCT06683833 | Phase 4 | Nov 20, 2024 | Cairo University |
| NCT06447519 | N/A | Sep 30, 2024 | Aristotle University of Thessaloniki |
| NCT06196515 | Phase 2/Phase 3 (Phase 3) | Aug 31, 2024 | British University In Egypt |
| NCT06378346 | Phase 2 | Jul 25, 2024 | University of Illinois at Chicago |
| NCT06342830 | Phase 2 | Jun 20, 2024 | Ain Shams University |
| NCT07123792 | N/A | Jun 3, 2024 | College of Physicians and Surgeons Pakistan, HITEC-Institute of Medical Sciences |
| NCT07057336 | N/A | May 14, 2024 | Cukurova University |
Showing 20 of 78 trials
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Organizations
Research & Development (44)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 22 | 22 | 5 | 2015 |
| Mansoura University | Academic/Hospital | 6 | 6 | 4 | 2019 |
| Al Azhar University | Academic/Hospital | 5 | 5 | 2 | 2013 |
| Azad University | Academic/Hospital | 3 | 3 | 2 | 2010 |
| College of Physicians and Surgeons Pakistan | Academic/Hospital | 3 | 2 | 1 | 2024 |
| Minia University | Academic/Hospital | 3 | 3 | 1 | 2020 |
| British University In Egypt | Academic/Hospital | 2 | 2 | 1 | 2024 |
| Ege University | Academic/Hospital | 2 | 2 | 1 | 2011 |
| Government of Pakistan | Government | 2 | 2 | 1 | 2022 |
| Istanbul Medipol University | Academic/Hospital | 2 | 2 | 2 | 2015 |
| University of Illinois at Chicago | Academic/Hospital | 2 | 2 | 2 | 2015 |
| University of Sao Paulo | Academic/Hospital | 2 | 1 | 2 | 2015 |
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Alexandria University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Altinbas University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Aristotle University of Thessaloniki | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Cukurova University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Dow University of Health Sciences | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Fausto Medeiros Mendes | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Fujian Medical University | Academic/Hospital | 1 | 1 | 1 | 2016 |
44 organizations
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