Drotaverine
Small moleculeexperimental
Clinical trial activity
4 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
1
Earliest trial started May 1, 2005 (NCT00292747)
Timeline
Indications
Approved for
Mechanism of action
Phosphodiesterase 4 and 5 (PDE4 and PDE5) antagonist
- Phosphodiesterase 4INHIBITOR
Phosphodiesterase 4 inhibitor
Inhibits phosphodiesterase 4 leading to a decrease in cyclic AMP and a reduction in calcium ions which dilates muscles/blood vessesl contributing to it's spasmolytic and vasodilating action.
Chemistry & pharmacology
Loading structure…
SMILES
CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC- Mol. weight
- 397.52 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL551978 ↗
Also known as
- 1-benzyl-3',4',6,7-tetraethoxy-1,2,3,4- tetrahydroisoquinoline
- dihydroethaverine
- dihydroethaverine
- dihydroisoperparine
- dihydroisoperparine
- dihydroisoperparine
- dihydroisoperparine
- dihydroisoperparine
- dihydroisoperparine
- drotaverin
- drotaverin
- drotaverin
- drotaverin
- drotaverine
- drotaverine
- drotaverine
- drotaverine
- drotaverine
- drotaverine
- drotaverine
- drotaverine hcl
- drotaverine hydrochloride
- drotaverine hydrochloride
- drotaverine hydrochloride
- drotaverin hydrochloride
- drotaverin hydrochloride
- drotin
- drotin
- isodihydroperparine
- isodihydroperparine
- no-shpa
- no-spa
- nospan
- nospanum
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01639027 | Phase 2/Phase 3 (Phase 3) | May 1, 2012 | Ain Shams University |
| NCT01236651 | Phase 2 | Nov 1, 2010 | Ain Shams University |
| NCT00731198 | Phase 3 | Aug 1, 2008 | Changhai Hospital |
| NCT00292747 | Phase 4 | May 1, 2005 | Sanofi, Sanofi-Aventis |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ain Shams University | Academic/Hospital | 2 | 2 | 2 | 2010 |
| Changhai Hospital | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Sanofi | For profit | 1 | 1 | 1 | 2005 |
| Sanofi-Aventis | For profit | 1 | 0 | 1 | 2005 |
4 organizations
Page 1 / 1