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cycloserine

Trade name: seromycin

Small moleculeapproved

Approved

Jun 29, 1964

Cycloserine was discovered simultaneously in 1954 by Eli Lilly and Merck. The drug was approved for the treatment of active pulmonary and extrapulmonary tuberculosis and marketed under the name Seromycin (among the others). Cycloserine suppresses the synthesis of bacterial wall by inhibitin two enzymes: alanine racemase and d-alanine ligase. — NCATS

Clinical trial activity

127 trials · 99 clinical orgs · 2 marketing orgs

Phase 1
20
Phase 2
55
Phase 3
26
Phase 4
15

Earliest trial started Jan 1, 1993 (NCT00000194)

Timeline

1960s

  1. Jun 29, 1964

    Purdue Pharmaceuticals — Earliest FDA Approval

  2. Jun 29, 1964

    Purdue Pharmaceuticals — Marketing Organization

  3. Jun 29, 1964

    Cerovene — Marketing Organization

  4. Jun 29, 1964

    Purdue Pharmaceuticals — NDA Organization

1990s

  1. Jan 1, 1993

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 1996

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedJun 29, 1964

Chemistry & pharmacology

Loading structure…

SMILES

N[C@@H]1CONC1=O
Mol. weight
102.0919 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Prescription Only

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • (+)-4-amino-3-isoxazolidinone
  • (+)-4-amino-3-isoxazolidinone
  • alpha-cycloserine
  • alpha-cycloserine
  • cicloserina
  • cicloserina
  • cyclo-d-serine
  • cyclo-d-serine
  • cyclorin
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • cycloserine
  • (+)-cycloserine
  • (+)-cycloserine
  • cycloserinum
  • cycloserinum
  • d-4-amino-3-isoxazolidinone
  • d-4-amino-3-isoxazolidinone
  • d-4-amino-3-isoxazolidone
  • d-4-amino-3-isoxazolidone
  • dcs
  • dcs
  • d-cycloserine
  • d-cycloserine
  • d-cycloserine
  • d-(+)-cycloserine
  • d-(+)-cycloserine
  • farmiserina
  • miroseryn
  • nrx-101
  • orientomycin
  • orientomycin
  • oxamycin
  • pa 94
  • pa 94
  • pa-94
  • pa-94
  • (r)-4-amino-1,2-oxazolidin-3-one
  • (r)-4-amino-isoxazolidin-3-one
  • (r)-4-amino-isoxazolidin-3-one
  • ro-1-9213
  • ro-1-9213
  • seromycin
  • seromycin
  • seromycin
  • seromycin
  • seromycin
  • α-cycloserine
  • α-cycloserine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07227103Phase 2/Phase 3 (Phase 3)Mar 1, 2026NeuroRx, Inc.
NCT07198685N/ASep 30, 2025Huazhong University of Science and Technology
NCT06825169Phase 1/Phase 2 (Phase 2)Mar 1, 2025Jiao Tong University, Nuwacell Biotechnologies Co., Ltd.
NCT06128213Phase 2Mar 31, 2024NeuroRx, Inc.
NCT06121284Phase 2Nov 30, 2023University of Alberta, University of Calgary
NCT06081361Phase 3Nov 1, 2023Capital Medical University
NCT05994703Phase 2Oct 20, 2023Foundation for a Smoke-Free World, Rose Research Center, LLC
NCT05591677Phase 2Dec 31, 2022Blue Bell Health, Australia, Griffith University, Monash University
NCT05731323Phase 1Oct 12, 2022University of Calgary
NCT05395494Phase 2Aug 29, 2022University of Calgary
NCT05306223Phase 4May 10, 2022Capital Medical University
NCT05177601Phase 2Nov 26, 2021University of Calgary
NCT05081986Phase 2Aug 17, 2021University of Calgary
NCT04762836N/AFeb 28, 2021Leiden University
NCT04717908N/AJan 20, 2021Fudan University
NCT04545788N/AAug 1, 2020Capital Medical University
NCT04357951Early Phase 1 (Phase 1)Jul 31, 2020Johns Hopkins University
NCT04035603Phase 2Oct 1, 2019Boston University, National Institute on Drug Abuse (NIDA)
NCT03780829Early Phase 1 (Phase 1)Jul 1, 2019Department of Veteran Affairs
NCT03937596Phase 2Jun 30, 2019University of Calgary
Showing 20 of 127 trials
Page 1 / 7

Organizations

Research & Development (99)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Harvard UniversityAcademic/Hospital171351996
Boston UniversityAcademic/Hospital14952003
National Institute of Mental Health (NIMH)Government14142000
National Institute on Drug Abuse (NIDA)Government10031993
University of CalgaryAcademic/Hospital9822015
Department of Veteran AffairsGovernment8551993
NeuroRx, Inc.For profit7732017
Emory UniversityAcademic/Hospital6332006
University of California, Los AngelesAcademic/Hospital5442000
Capital Medical UniversityAcademic/Hospital4432019
Columbia UniversityAcademic/Hospital4432008
Hoosier Cancer Research NetworkAcademic/Hospital4422006
Northwestern UniversityAcademic/Hospital4432006
Southern Methodist UniversityAcademic/Hospital4132007
Target Health Inc.For profit4012017
University of ConnecticutAcademic/Hospital4332003
Brain & Behavior Research FoundationAcademic/Hospital3022004
Department of DefenseGovernment3012010
Indiana UniversityAcademic/Hospital3312004
National Institutes of Health (NIH)Government3012003
99 organizations
Page 1 / 5

Marketing (4)

OrganizationOrg typeRelationshipDate
CeroveneFor profitMKTGJun 29, 1964
Purdue PharmaceuticalsFor profitMKTGJun 29, 1964
Purdue PharmaceuticalsFor profitNDAJun 29, 1964
Purdue PharmaceuticalsFor profitSYNJun 29, 1964