sd-101
Small moleculeexperimental
Clinical trial activity
21 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
17
Phase 2
9
Phase 3
1
Phase 4
0
Earliest trial started Jan 1, 2008 (NCT00599001)
Timeline
Indications
Studied for
- Carcinoma, Hepatocellular · Phase 1/Phase 2
- Cholangiocarcinoma · Phase 1/Phase 2
- Colorectal Neoplasms · Early Phase 1
- Epidermolysis Bullosa · Phase 3
- Head and Neck Neoplasms · Phase 1/Phase 2
- Healthy Volunteers · Phase 1
- Hepatitis C, Chronic · Phase 1
- Hodgkin Disease · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1/Phase 2
- Lymphoma · Phase 1/Phase 2
- Lymphoma, B-Cell · Phase 1/Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 1/Phase 2
- Lymphoma, Follicular · Phase 1/Phase 2
- Lymphoma, Mantle-Cell · Phase 1/Phase 2
- Lymphoma, Non-Hodgkin · Phase 1
- Melanoma · Phase 1/Phase 2
- Neoplasms · Phase 1/Phase 2
- Pancreatic Neoplasms · Phase 1
- Prostatic Neoplasms · Phase 2
Mechanism of action
- Toll-like receptor 9AGONIST
TLR9 agonist
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL6068457 ↗
Also known as
- sd-101
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07172282 | Early Phase 1 (Phase 1) | Nov 1, 2025 | Northwell Health |
| NCT06710223 | Phase 1 | Dec 31, 2024 | TriSalus Life Sciences, University of California, San Diego |
| NCT05607953 | Phase 1 | Nov 30, 2022 | TriSalus Life Sciences |
| NCT05220722 | Phase 1/Phase 2 (Phase 2) | Mar 2, 2022 | TriSalus Life Sciences |
| NCT04935229 | Phase 1 | Aug 2, 2021 | TriSalus Life Sciences |
| NCT04050085 | Phase 1 | Aug 2, 2019 | Bristol-Myers Squibb, Dynavax Technologies Corporation, National Cancer Institute (NCI), University of California, Davis |
| NCT03831295 | Phase 1 | Mar 13, 2019 | Bristol-Myers Squibb, Stanford University |
| NCT03410901 | Phase 1 | Apr 9, 2018 | National Cancer Institute (NCI), Stanford University |
| NCT03322384 | Phase 1/Phase 2 (Phase 2) | Jan 17, 2018 | University of California, Davis |
| NCT03007732 | Phase 2 | Apr 27, 2017 | University of California, San Francisco |
| NCT02927964 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2016 | National Cancer Institute (NCI), Stanford University |
| NCT02731742 | Phase 1 | Jun 22, 2016 | Merck |
| NCT02521870 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2015 | Dynavax Technologies Corporation, Merck, University of California, Los Angeles |
| NCT02384460 | Phase 3 | Mar 1, 2015 | Amicus Therapeutics, Scioderm, Inc. |
| NCT02266147 | Phase 1/Phase 2 (Phase 2) | Oct 1, 2014 | Dynavax Technologies Corporation |
| NCT02254772 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2014 | National Cancer Institute (NCI), Stanford University |
| NCT02090283 | N/A | Mar 1, 2014 | Scioderm, Inc. |
| NCT02014376 | Phase 2 | Jan 1, 2014 | Scioderm, Inc. |
| NCT01745354 | Phase 1 | Aug 1, 2012 | Stanford University |
| NCT00823862 | Phase 1 | Oct 1, 2008 | Dynavax Technologies Corporation, Medical University of Warsaw, PPD, Synteract, Inc. |
Showing 20 of 21 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Dynavax Technologies Corporation | For profit | 5 | 4 | 2 | 2008 |
| Stanford University | Academic/Hospital | 5 | 5 | 2 | 2012 |
| National Cancer Institute (NCI) | Government | 4 | 0 | 2 | 2014 |
| TriSalus Life Sciences | For profit | 4 | 3 | 2 | 2021 |
| Scioderm, Inc. | For profit | 3 | 3 | 3 | 2014 |
| Bristol-Myers Squibb | For profit | 2 | 0 | 1 | 2019 |
| Merck | For profit | 2 | 1 | 2 | 2015 |
| University of California, Davis | Academic/Hospital | 2 | 2 | 2 | 2018 |
| Amicus Therapeutics | For profit | 1 | 0 | 1 | 2015 |
| Healthcare Discoveries Inc. | For profit | 1 | 0 | 1 | 2008 |
| Medical University of Warsaw | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Northwell Health | Academic/Hospital | 1 | 1 | 1 | 2025 |
| PPD | For profit | 1 | 0 | 1 | 2008 |
| Synteract, Inc. | For profit | 1 | 0 | 1 | 2008 |
| University of California, Los Angeles | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of California, San Diego | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of California, San Francisco | Academic/Hospital | 1 | 1 | 1 | 2017 |
17 organizations
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